Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-07-08
1989-10-10
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142378, 5142388, 5142392, 514374, 5142395, 5142335, A61K 31535, A61K 3142
Patent
active
048732400
ABSTRACT:
A method for increasing the weight gain and/or improving the feed utilization efficiency of livestock is described which comprises the oral or non-oral administration to livestock of an effective, non-toxic amount of a compound of formula (XX): ##STR1## or a salt thereof, in which W is phenyl optionally substituted by halogen or trifluoromethyl, or a benzofuran-2-yl group, R.sup.1x is hydrogen or methyl, R.sup.2x is carboxyl or a group O--Z.sup.4 --CO.sub.2 H or an ester or amide thereof; a group O--E.sup.1 --NR.sup.3x R.sup.4x or a group O--E.sup.1 --OR.sup.5x, wherein R.sup.3x, R.sup.4x and R.sup.5x each represents hydrogen or C.sub.1-6 alkyl, Z.sup.4 is a C.sub.1-6 straight or branched alkylene chain, x is 1 or 2, y is 2 or 3, and E.sup.1 is C.sub.2-7 straight or branched alkylene chain with at least two carbon atoms separating the two heteroatoms in the group R.sup.2x. Also described is a veterinarily acceptable premix formulation administrable in a veterinarily effective amount in feed or water comprising a compound of the formula (XX) or, where appropriate, a veterinarily acceptable salt, ester or amide thereof; in association with a veterinarily acceptable carrier therefor. Additionally, a veterinarily acceptable premix formulation comprising from about 0.001% to about 95% by weight of a compound of formula (XX) administrable in feed or water or, where appropriate, a veterinarily acceptable salt, ester or amide thereof, together with a veterinarily acceptable carrier.
REFERENCES:
patent: 4607033 (1986-08-01), Cantello
Chemical Abstracts, vol. 103 1985, 123489u.
Beecham Group p.l.c.
Waddell Frederick E.
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