Method for activating prothrombin with polyethylene glycol

Details Method for activating prothrombin with polyethylene glycol Method for activating prothrombin with polyethylene glycol

1997-08-01

1998-09-22

Weber, Jon P.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

424 9464, C12N 974, A61K 3848

Patent

active

058112790

ABSTRACT:
A method for activating prothrombin to thrombin is presented which comprises treating an aqueous solution containing prothrombin with polyethylene glycol in the presence or absence of the calcium salt. The method enables conversion of prothrombin to thrombin in the absence of thromboplastin and allows for preparation of thrombin on an industrially large scale from easily available starting materials.

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Abshire et al. (1995) Blood, 86(10 Suppl. 1), "Activated Coagulation in Pents Receiving Polyethylene Glycol Conjugated L-Asparaginase (PEG-Asp)", p. 863A, Abstract No. 3438.
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