Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2006-12-21
2011-11-22
Saidha, Tekchand (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
Reexamination Certificate
active
08062876
ABSTRACT:
Methods for converting prethrombin-1 to thrombin are disclosed. An aqueous solution of prethrombin-1 is applied to oscutarin-C immobilized on a solid support so as to provide from 500 mg to 4000 mg of prethrombin-1 per mL of the solid support and a contact time between the prethrombin-1 and the oscutarin-C of from 1.8 to 3.5 minutes. The resulting active thrombin may be captured on an ion exchange chromatography medium or an affinity chromatography medium.
REFERENCES:
patent: 03/070746 (2003-08-01), None
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Australian Office Action mailed May 13, 2009.
Boone Jonathon C.
De Jongh Karen S.
Forstrom John W.
Mallett Robert W.
Stenland Christopher J.
Meah Md. Younus
Nixon & Peabody LLP
Saidha Tekchand
Webster Mary S.
Zymogenetics Inc.
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