Method for activating NKT cells using PIMs

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se

Reexamination Certificate

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C435S375000, C435S383000

Reexamination Certificate

active

07052909

ABSTRACT:
The invention concerns a pharmaceutical composition comprising at least a PIM-activated NKT cell and the use of at least one PIM and/or a PIM-activated NKT cell for treating a disease for which a granulomatous type of immune response is desired.

REFERENCES:
patent: WO 99/12562 (1999-03-01), None
patent: WO 99/52547 (1999-10-01), None
Apostolou et al. PNAS, 1999, v.96, pp. 5141-5146.
Gilleron et al., J of Biol. Chem. 2003, v.278, p 29880-29889.
Apostolou, I. et al., “Murine Natural Killer Cells Contribute to the Granulomatous Reaction Caused by Mycobacterial Cell Walls”, Proc. Natl. Acad. Sci. USA, vol. 96, pp. 5141-5146, (1999).
Kobayashi, E. et al., “Enhancing Effects of Agelasphin-11 on Natural Killer Cell Activities of Normal and Tumor-Bearing Mice”, Bio. Pharm. Bul., vol. 19, No. 3, pp. 350-353, (1996).
Stankova, J. et al., “Fucose-Activated Killer (FAK) Cells: Anomalous Killers with Augmented Cytotoxic Activity”, The Journal of Immunology, vol. 135, No. 6, pp. 3719-3728, (1985).
Kawano, T. et al., “Use of an Alpha-glycosyl-Ceramide of Formula (I) or Its Salt or Solvate as a Natural Killer (NK) T Cell Activator . . . ,”, Derwent Publications Ltd., London, GB: Abstract of WO 98 44928 A1, (1 page), (1998).

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