Method for accessing microbial diversity

Details Method for accessing microbial diversity Method for accessing microbial diversity

2003-01-22

2009-02-24

Chen, Shin-Lin (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of co-culturing cells

C435S004000, C435S006120, C435S375000, C530S350000

Reexamination Certificate

active

07494810

ABSTRACT:
A method of interfering with quorum sensing regulation of genes to promote cell growth is disclosed. The method of is aimed at accessing microbial biodiversity. The method involves obtaining an environmental sample comprising at least one novel (uncultivated in the laboratory) microorganism, contacting the environmental sample with an effective amount of an agent or combination of agents which interferes with the quorum sensing regulation of genes, growing the treated sample in a culture medium containing the quorum sensing signal disrupting agent or agents, and analyzing the colonies of microorganisms grown to demonstrate genetic novelty.

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De Kievit et al., 1999, Science & Medicine, vol. 6, No. 6, p. 42-50.
Bauer et al., 2002, Current Opinion in Biotechnology, vol. 13, p. 234-237.
Branny et al., “Inhibition of Quorum Sensing by aPseudomonas aeruginosadksA Homologue,”Journal of Bacteriology, Mar. 2001, vol. 183, No. 5, p. 1531-1539.
Lin et al., Acyl-Homoserine Lactone Acylase fromRalstoniaStrain Xj12B Represents a Novel and Potent Class of Quorum-quenching Enzymes,Molecular Microbiology, Feb. 2003, vol. 47, No. 3, p. 849-860.
Guan et al., “Bacterial response to siderophore and quorum-sensing chemical signals in the seawater microbial community”, BMC Microbiology, vol. 1, No. 27, (Oct. 23, 2001), pp. 1-11, URL, XP-002314547.

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