Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2004-07-23
2011-10-04
Lu, Frank W (Department: 1634)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S006120, C435S091100, C435S091510, C436S094000, C536S023100, C536S024300, C536S024330
Reexamination Certificate
active
08030031
ABSTRACT:
This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA. Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue.
REFERENCES:
patent: 4350156 (1982-09-01), Malchesky
patent: 4631130 (1986-12-01), Watanabe
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4699877 (1987-10-01), Cline et al.
patent: 4738927 (1988-04-01), Taniguchi
patent: 4874853 (1989-10-01), Rossi
patent: 4874858 (1989-10-01), Magistro
patent: 4999290 (1991-03-01), Lee
patent: 5087617 (1992-02-01), Smith
patent: 5098890 (1992-03-01), Gerwitz et al.
patent: 5124246 (1992-06-01), Urdea et al.
patent: 5155018 (1992-10-01), Gillespie et al.
patent: 5217889 (1993-06-01), Roninson et al.
patent: 5274087 (1993-12-01), Barnett et al.
patent: 5300635 (1994-04-01), Macfarlane
patent: 5409818 (1995-04-01), Davey et al.
patent: 5429923 (1995-07-01), Seidman
patent: 5470724 (1995-11-01), Ahern
patent: 5506106 (1996-04-01), Croce
patent: 5532220 (1996-07-01), Lee et al.
patent: 5576178 (1996-11-01), Emanuel
patent: 6001987 (1999-12-01), Perron
patent: 6051374 (2000-04-01), Simons
patent: 6057105 (2000-05-01), Hoon
patent: 6329179 (2001-12-01), Kopreski
patent: 6344317 (2002-02-01), Urnovitz
patent: 6607898 (2003-08-01), Kopreski et al.
patent: 6759217 (2004-07-01), Kopreski
patent: 6794135 (2004-09-01), Kopreski
patent: 6916634 (2005-07-01), Kopreski
patent: 6939671 (2005-09-01), Kopreski
patent: 2004/0058331 (2004-03-01), Akagi
patent: 3717212 (2003-09-01), None
patent: WO 90/09456 (1990-08-01), None
patent: WO9009456 (1990-08-01), None
patent: 97/35589 (1997-10-01), None
patent: 98/14617 (1998-04-01), None
patent: 99/67397 (1999-12-01), None
Attached definition for “oncogene” from Web.
Rykova et al., Concentrations of circulating RNA from healthy donors and cancer patients estimated by different methods. Ann. N.Y. Acad. Sci., 1075, 328-333, 2006.
Arcariet al., The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: evidence for multiple mRNA species. Nucleic Acids Research, 12, 9179-9189, 1984.
The definitions for “extracellular” and “intracellular” from Wikipedia, the free encyclopedia. Printed on May 15, 2009.
Tsui et al., Stability of Endogenous and Added RNA in Blood Specimens, Serum, and Plasma. Clin. Chem., 48, 1647-1653, 2002.
Kopreski et al., “Detection of tumor messenger RNA in the serum of patients with malignant melanoma.” Clinical Cancer Research 5:1961-65 (Aug. 1999) 5:1961-65.
Leitzel et a., “Detection of cancer cells in peripheral blood of breast cancer patients using reverse transcription-polymerase chain reaction for epidermal growth factor receptor.” Clinical Cancer Research 4:3037-43 (Dec. 1998).
Tamamiyagi et al., “Quantitative analysis of ferrochelatase mRNA in blood cells of erythropoietic protoprophyria patients.” Journal of Dermatological Science 11(2)154-60 (Feb. 1996).
Garbarz et al.,“Spectrin Beta-Tandil A Novel Shortened Beta-Chain Variant Associated with Hereditary Elliptocytosis is due to a Deletional Frameshift Mutation in the Beta Spectrin Gene,” Blood 80(4)1066-73 (1992).
Monteyne et al., “Expression of costimulatory molecules and cytokines in CSF and peripheral blood mononuclear cells from multiple sclerosis patients” Acta Neurological Belgica 1(99):11-20 (Mar. 1999).
Serra et al., “Multiple sclerosis and multiple sclerosis-associated retrovirus in Sardinia” Neurological Sciences 22(2) 171-73 (Apr. 2001).
Kopreski et al., “Cellular-versus extracellular-based assays. Comparing utility in DNA and RNA molecular marker assessment” Annals of New York Academy of Sciences 906:124-8 (Apr. 2000).
Messner et al., “Expression of messenger RNA of the cardiac isoforms of troponin T and I in myopathic skeletal muscle” American Journal of Clinical Pathology 114(4)544-49(Oct. 2000).
Kamm et al., “Nucleic-Acid Concentrations in Normal Human Plasma” Clinical Chemistry 18(6)519-22 (1972).
Shutack et al., “A Study of the RNA levels of normal blood serum” The Journal of the American Osteopathic Association 67(9)1051-53 (May 1968).
Guin et al., “Electrophoretic Characterization of Plasma RNA” Biochemical Medicine 13(3)224-30 (1975).
Stroun et al., “Presence of RNA in the nucleoprotein complex spontaneously released by human lymphocytes and frog auricles in culture” Cancer Research 38(10)3546-3554 (Oct. 1978).
Allouche et al., “Expression of basic fibroblast growth factor (bFGF) and FGF-receptors in human leukemic cells” Leukemia:Official Journal of the Leukemia Society of America, Leukemia Reserach Fund 9(1)77-86 (Jan. 1995).
Ricchiuti et al., “Expression of cardiac troponin T mRNA in skeletal muscle from patients with end stage renal disease and muscular dystrophy” Clinical Chemistry 45(6)A144-A145 (Jun. 1999).
Ricchiuti et al., “RNA expression of cardiac troponin T isoforms in diseased human skeletal muscle” Clinical Chemistry 45(12)2129-35 (Dec. 1999).
Ricchiuti et al., “Cardiac troponin I and T alterations in hearts with severe left ventricular remodeling” Clinical Chemistry 43(6)990-95 (1997).
Rosenzweig et al., “Preclinical Diagnosis of Familial Hypertrophic Cardiomyopathy by Genetic Analysis of Blood Lymphocytes” New England Journ of Med 325(25)1753-60 (Nov. 19, 1981).
Spiegelman et al., “The Development and Use of and Extracellular RNA Replicating System” The Harvey Lectures No. 64 pp. 1-67 (1969).
Abravaya et al., “Detection of point mutations with a modified ligase chain reaction (GAP-LCR),”Nucleic Acids Research23:675-682 (1995).
Alkema et al., “Characterization and Chromosamal Localization of the Human Prata-Oncogene BMI-1,”Human Mol Genet2:1597-1603 (1993).
Aoki et al., “Liposome-mediated in viva gene transfer on antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity,”Cancer Research55:3810-3816 (1995).
Barz et al., “Characterization of Cellular and Extracellular Plasma Membrane Vesicles from a Non-metastasing Lymphoma (Eb) and Its Metastasing Variant (Esb),”Biochin Biophys Acta814:77-84 (1985).
Bauer et al., “Identification of H-2Kb Binding and Immunogenic Peptides from Human Papillama Virus Tumour Antigens E6 and E7,”Scand J Immunol42:317-323 (1995).
Blackburn et al., “Electrochemiluminescence detection for development of immunoassays and DNA probe assays for clinical diagnostics,”Olin Chem37/9:1534-1539 (1991).
Bobo et al., “Diagnosis ofChlamydia trachomatiscervical infection by detection of amplified DNA with an enzyme immunoassay,”J din Micra28:1968-1973 (1990).
Bocchia et al., “Specific Binding of Leukemia Oncogene Fusion Peptides to HLA Class I Molecules,”Blood85:2680-2684 (1995).
Boom et al., “Rapid and Simple Method for Purification of Nucleic Acids,”J Clin Micro28:495-503 (1990).
Boom et al., “Rapid Purification of Hepatitis B Virus DNA from Seruc,”J Clin Micro29:180-181 (1991).
Brossart et al., “Detection of residual tumor cells in patients with malignant melanoma responding to immunotherapy,”J Immunotherapy15:38-41 (1994.
Buchman et al., ȁ
Lu Frank W
McDonnell & Boehnen Hulbert & Berghoff
OncoMedx, Inc.
LandOfFree
Method enabling use of extracellular RNA extracted from... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method enabling use of extracellular RNA extracted from..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method enabling use of extracellular RNA extracted from... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4266144