Method, DNA and bacteria for hyperproduction of an antibiotic du

Details Method, DNA and bacteria for hyperproduction of an antibiotic du Method, DNA and bacteria for hyperproduction of an antibiotic du

1997-02-06

1999-03-02

Guzo, David

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

43525235, 536 232, 536 237, C12N 1510, C12N 121, C07H 2104

Patent

active

058769870

ABSTRACT:
A recombinant Streptomyces sp. which exhibits hyperproduction of an antibiotic, particularly actinorhodin and undecylprodigiosin, as a result of interruption of the absA homologous locus of chromosomal DNA (SEQ ID NO:1) is described. The gene is thought to encode a histidine kinase and a response regulator. The preferred bacterium is Streptomyces coelicolor. It is preferred to interrupt the absA1 gene with ermE DNA.

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