Method, composition and device for measuring the ionic strength

Details Method, composition and device for measuring the ionic strength Method, composition and device for measuring the ionic strength

1994-03-25

1995-04-04

Housel, James C.

Chemistry: analytical and immunological testing

Process or composition for determination of physical state...

436 74, 436169, 422 56, G01N 936

Patent

active

054037441

ABSTRACT:
A method, composition and test device for determining the ionic strength or specific gravity of a test sample are disclosed. The method utilizes a test device comprising a test pad, wherein the test pad includes a carrier matrix incorporating a reagent composition capable of producing a detectable and measurable response that correlates to the ionic strength and the buffer capacity, and therefore the specific gravity, of the test sample. The reagent composition, comprising a strong polyelectrolyte, an indicator comprising: (i) a dye that is metachromatic and sensitive to pH changes, or (ii) or a combination of metachromatic dye and a pH indicator dye, in a suitable carrier, and buffered at a pH of 3 or less, is incorporated into a carrier matrix to provide a test pad of a device useful in an ionic strength or specific gravity assay of a test sample.

REFERENCES:
patent: 4318709 (1982-03-01), Falb et al.
patent: 4376827 (1983-03-01), Stiso et al.
Vitagliano, V., "Interaction Between Cationic Dyes and Polyelectrolytes." Chemical and Biological Applications of Relaxation Spectrometry, pp. 437-466 (1975), E. Wyn-Jones, Ed.

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