Surgery – Truss – Pad
Patent
1988-09-22
1991-02-05
Coven, Edward M.
Surgery
Truss
Pad
128401, 128784, 604 51, 6048901, 6048921, 606 27, 606 31, A61F 700, A61M 3700
Patent
active
049896016
ABSTRACT:
Method, apparatus, and a substance is disclosed for releasing at a temperature above normal tissue temperature an anti-cancer drug and applying heat in combination to tissue having neoplastic cells such as a malignant brain tumor. The apparatus comprises a probe having a semi-rigid elongated member that is interstitially implanted in the malignant tumor. The elongated member is coated with a carrier substance that is responsive at a temperature above normal tissue temperature for releasing a carried substance such as a therapeutic anti-cancer drug. Within the elongated member, an electrical heater element produces heat when energized for heating the probe, the carrier substance, the anti-cancer drug, and the surrounding tissue. An electrical thermistor is also included within the elongated member for measuring the temperature of the probe in order to regulate the release of the drug and the temperature of the surrounding tissue. The method includes interstitially implanting the elongated member of the probe in the tumor, energizing the electrical heater element, releasing the drug in response to the heat to effect one treatment, and heating the tissue and drug to effect a second treatment. The combination of the heat and drug treatments then has an effectiveness level greater than the effectiveness levels of the heat and drug treatments individually. The coating layer substance includes a combination of a carrier and a carried substance for releasing the carried substance at a predetermined temperature above normal tissue temperature.
REFERENCES:
patent: 1707762 (1929-04-01), Homan
patent: 2777445 (1957-01-01), Hart
patent: 3170465 (1965-02-01), Henney et al.
patent: 3369549 (1968-03-01), Armao
patent: 3901224 (1975-08-01), Bucalo
patent: 3938526 (1976-02-01), Anderson et al.
patent: 3942535 (1976-03-01), Schulman
patent: 3949388 (1976-04-01), Fuller
patent: 4030499 (1977-06-01), Bucalo
patent: 4046139 (1977-09-01), Horn
patent: 4106488 (1978-08-01), Gordon
patent: 4142529 (1979-03-01), Latenser et al.
patent: 4146029 (1979-03-01), Ellinwood
patent: 4223678 (1980-09-01), Langer et al.
patent: 4227535 (1980-10-01), Connor
patent: 4232679 (1980-11-01), Schulman
patent: 4239040 (1980-12-01), Hosoya et al.
patent: 4275738 (1981-06-01), McDonald et al.
patent: 4312364 (1982-01-01), Convert
patent: 4331161 (1982-05-01), Patel
patent: 4333469 (1982-06-01), Jeffcoat et al.
patent: 4360028 (1982-11-01), Barbier et al.
patent: 4465069 (1984-08-01), Barbier et al.
patent: 4483341 (1984-11-01), Witteles
patent: 4558690 (1985-12-01), Joyce
patent: 4572214 (1986-02-01), Nordenstrom et al.
patent: 4577642 (1986-03-01), Stokes
patent: 4591496 (1986-05-01), Cohen et al.
patent: 4638045 (1987-01-01), Kohn et al.
patent: 4642111 (1987-02-01), Sakamoto et al.
patent: 4654024 (1987-08-01), Crittenden et al.
patent: 4679561 (1987-08-01), Doss
patent: 4709698 (1987-12-01), Johnson et al.
patent: 4719919 (1988-01-01), Marchosky et al.
patent: 4739771 (1988-04-01), Manwaring
patent: 4744370 (1988-05-01), Harris
patent: 4744933 (1988-05-01), Rha et al.
patent: 4749620 (1988-06-01), Rha et al.
patent: 4763671 (1988-08-01), Goffinet
patent: 4781676 (1988-11-01), Schweighardt et al.
patent: 4800899 (1989-01-01), Elliott
patent: 4801459 (1989-01-01), Liburdy
"Combined Treatment of Solid Tumor by Local Hyperthermia and Actinomycin D", A. Yerushalmi, Br. J. Cancer (1978) 37,827.
Blackshear, "Implantable Drug Delivery Systems" Scientific American, Dec. 1979, pp. 66-73.
Hornback, Ned B., "Hyperthermia and Cancer", 1984, Chapter I, vol. I.
Storm, Kristian, "Hyperthermia in Cancer Therapy", 1983, Table of Contents.
Nussbaum, Gilbert H., "Physical Aspects of Hyperthermia", 1982, Table of Contents.
Parsonnet et al., "An Experimental Method for Thermal Control of Heart Rate: Work in Progress", Pace, Sep.-Oct., 1980.
Murawski et al., "An Externally Programmable, Implantable, Integrated Cerebellar Stimulator", IEEE in Medicine & Biology Society, 1982.
Taylor, "Brain Cancer Therapy Using an Implanted Microwave Radiator", Microwave Journal, 1981.
Sutton, Carl H., "Tumor Hyperthermia in the Treatment of Malignant Gliomas of the Brain", Transactions of the American Neurological Association, 96:195-199, 1971.
Anghileri, Leopold et al., [Eds.], Hyperthermia in Cancer Treatment, CRC Press, Inc., Boca Raton, Fla., 1986, pp. 26, 44, 126, 136-138.
Pacela et al., "New Copolymer Will Administer Brain Cancer Drug", Biomedical Technology, vol. 14, No. 24, Nov. 15, 1987, p. 244.
Mulcahy, "Hyperthermia and Chemotherapy", Syllabus: A Categorical Course in Radiator Therapy: Hyperthermia, Radiological Society of North America, No. 29-Dec. 4, 1987, pp. 27-35.
Tamargo et al., "Growth Inhibition of the 9L Gliosarcoma by the Local Sustained Release of BCNU: A Comparison of Systemic Versus Regional Chemotherapy", Scientific Program the Meeting of the American Association of Neuroiogical Surgeons, Apr. 24-28, 1988, Toronto, Ontario, p. 212.
Brem et al., "A Biodegradable Polymer for Intracranial Drug Delivery: A Radiological Study in Primates", Scientific Program: The Annual Meeting of the American Association of Neurological Surgeons, Apr. 24-28, 1988, Toronto, Ontario, pp. 381-382.
Brem et al., "Biocompatibility of a BCNU-Loaded Biodegradable Polymer: A toxicity Study in Primates", Scientific Program: The Anual Meeting of the American Association of Neurological Surgeons, Apr. 24-28, 1988, Toronto, Ontario, pp. 381-382.
Tamargo et al., "Brain Biocompatibility of a Biodegradable Polymer Capable of Sustained Release of Macromolecules", Scientific Program: The Annual Meeting of the American Association of Neurological Surgeons, Apr, 24-28, 1988, Toronto, Ontario, pp. 399-400.
Yang et al., "Sustained Systemic Delivery of BCNU from an Intraperitoneal Polymer Implant", Scientific Program: The Annual Meeting of the American Association of Neurological Surgeons, Apr. 24-28, Toronto, Ontario, p. 414.
Leong et al., "Bioerodible Polyanhydrides as Drug-Carrier Matrices. II. Biocompatibility and Chemical Reactivity", Journal of Biomedical Materials Research, vol. 20, 1986, pp. 51-64.
Leong et al., "Bioerodible Polyanhydrides for Cancer Chemotherapy", Proceed. Intern. Symp. Control. Bioact. Mater., 12, 1985, pp. 106-107.
Rosen et al., "Bioerodible Polyanhydrides for Controlled Drug Delivery", Biomaterials, 1983, vol. 4, Apr., pp. 131-133.
Leong et al., "Bioerodible Polyandrides as Drug-Carrer Matrices. I: Characterization, Degradation, and Release Characteristics", Journal of Biomedical Materials Research, vol. 19, 1985, pp. 941-955.
Beck et al., "An Overview of the FDA Approved Controlled-Release Polymeric Materials", Proceed Intern. Symp. Control. Rel. Bioact. Mater., 12, 1985, p. 214.
Langer, Robert S., "New Drug Delivery Systems: What the Clinician Can Expect", Drug Therapy, Apr., 1983, pp. 217-231.
Langer, et al., "Biocompatibility of Polymeric Delivery Systems for Macromolecules", Journal of Biomedical Materials Research, vol. 15, 1981, pp. 267-277.
Kenealy, Dr. J., "Safety and Efficacy of BCNU Delivered from a Biodegradable", Surgically Implanted Polymer for the Treatment of Grade III or IV Astrocytoma, Protocol NPC8701, Nova Pharmaceutical Corp., pp. 1-15.
"Treatment of Grade III and IV Anaplastic Glioma by Means of Controlled Release of Carmustine (BCNU) from Biodel.RTM., a Biodegradable Polymer", Investigator's Brochure, Nova Pharmaceutical Corporation, Jul. 20, 1988, pp. 1-32.
Brem et al., "Biocompatibility of a Biodegradable, Controlled-Release Polymer in the Rabbit Brain", The John Hopkins University School of Medicine, Baltimore, MD, 1988.
Grossman et al., "The Intracerebral Delivery of BCNU with Surgically Implanted Biodegradable Polymers: A Quantitative Autoradiographic Study", Proceedings of ASCO, vol. 7, Mar. 1988, p. 84.
Weiss, Rick, "Delivering the Goods: Designing a New Drug is One Thing; Getting it to the Disease is Another", Science News, vol. 133, pp. 360-362, Jun. 1988.
Langer et al., "Controlled Release: Three Mechanisms", Chemtech, Feb., 1986, pp. 108-110.
Tamargo et al., "Brain Biocompatibility of a Biodegradable Controlled-R
Fearnot Neal E.
Marchosky Jose A.
Moran Christopher J.
Coven Edward M.
Godlewski Richard J.
Harrison Jessica J.
Medical Engineering & Development Institute, Inc.
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