Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1985-04-09
1986-10-07
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
530403, 530405, 530825, 435882, 435883, A61K 39085
Patent
active
046158847
ABSTRACT:
Inactivated staphylococcal alpha toxin which is in a detoxified immunogenically active form prepared as a vaccine and administered parenterally to patients having multiple sclerosis or other disease involving demyelination of nerve sheath myelin. The amount of the inactivated alpha toxin administered is sufficient to effectively immunize the patient against active staphylococcal alpha toxin. The patient becomes subsequently infected with staphylococcus, the alpha toxin resulting from the infection is neutralized by the alpha toxin binding antibodies. This prevents exacerbation of the demyelination of the nerve sheaths, which otherwise can be promoted by the alpha toxin resulting from the staphylococcus infection.
REFERENCES:
J. Bacteriology, 96, 1429-1430 (1966), Bernheimer et al.
Biochem. 12, 2672-2677 (1973), Six et al.
Science, 191, 380-383 (1976), Bock et al.
Canadian Journal of Microbiology, 25, 686-692 (1979), Lo et al.
Molecular & Cellular Biochem. 23, 143-152 (1979), Harshman.
Pharmacol. Ther. 19, 55-106 (1983), Freer et al.
Schain Howard E.
Vanderbilt University
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