Method and system of using intrinsic-based photosensing with...

Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

08068899

ABSTRACT:
Biological thick tissue such as skeletal and cardiac muscle is imaged by inserting a probe into the tissue and scanning the tissue at a sufficiently fast rate to mitigate motion artifacts due to physiological motion. According to one example embodiment, such a probe is part of a system that is capable of reverse-direction high-resolution imaging without staining or otherwise introducing a foreign element used to generate or otherwise increase the sensed light. The probe includes a light generator for generating light pulses that are directed towards structures located within the thick tissue. The light pulses interact with intrinsic characteristics of the structures to generate a signal such as SHG or intrinsic fluorescence. Reliance on intrinsic characteristics of the structures is particularly useful for applications in which the introduction of foreign substances to the thick tissue is undesirable.

REFERENCES:
patent: 3655259 (1972-04-01), Miyauchi et al.
patent: 4270843 (1981-06-01), Goto
patent: 4416519 (1983-11-01), Kobayashi
patent: 4515444 (1985-05-01), Prescott et al.
patent: 4570641 (1986-02-01), Lieber et al.
patent: 4693606 (1987-09-01), Podolsky et al.
patent: 5056530 (1991-10-01), Butler et al.
patent: 5093719 (1992-03-01), Prescott
patent: 5161063 (1992-11-01), Krill et al.
patent: 5181511 (1993-01-01), Nickolls et al.
patent: 5361166 (1994-11-01), Atkinson et al.
patent: 5457576 (1995-10-01), Atkinson et al.
patent: 5929985 (1999-07-01), Sandison et al.
patent: 6208886 (2001-03-01), Alfano et al.
patent: 6542665 (2003-04-01), Reed et al.
patent: 6546278 (2003-04-01), Walsh
patent: 6571118 (2003-05-01), Utzinger et al.
patent: 6580941 (2003-06-01), Webb
patent: 6639674 (2003-10-01), Sokolov et al.
patent: 6643071 (2003-11-01), Schnitzer
patent: 6760112 (2004-07-01), Reed et al.
patent: 6766184 (2004-07-01), Utzinger et al.
patent: 6785471 (2004-08-01), Lee et al.
patent: 6795199 (2004-09-01), Suhami
patent: 6839483 (2005-01-01), Reed et al.
patent: 6839586 (2005-01-01), Webb
patent: 6889075 (2005-05-01), Marchitto et al.
patent: 6967725 (2005-11-01), Denk et al.
patent: 7091500 (2006-08-01), Schnitzer
patent: 7414729 (2008-08-01), Xie et al.
patent: 2002/0139920 (2002-10-01), Seibel et al.
patent: 2002/0140942 (2002-10-01), Fee et al.
patent: 2002/0141714 (2002-10-01), Reed et al.
patent: 2003/0031410 (2003-02-01), Schnitzer
patent: 2003/0103262 (2003-06-01), Descour et al.
patent: 2003/0118305 (2003-06-01), Reed et al.
patent: 2004/0143190 (2004-07-01), Schnitzer
patent: 2004/0254474 (2004-12-01), Seibel et al.
patent: 2004/0260148 (2004-12-01), Schnitzer
patent: 2005/0157981 (2005-07-01), Berier et al.
patent: 2005/0207668 (2005-09-01), Perchant et al.
patent: 2005/0242298 (2005-11-01), Genet et al.
patent: 2009/0323059 (2009-12-01), Sun et al.
Armstrong et al. “In vivo size and shape measurement of the human upper airway using endoscopic longrange optical coherence tomography,” Opt. Express 11, 1817-1826 (2003).
Brown et al. “Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.” Nature Medicine 9, 796-800 (2003).
Delp et al. “OpenSim: Open-Source Software to create and analyze dynamic simulations of movement.” Biomedical Engineering IEEE 54, 1940-1950 (Nov. 2007) Abstract Only.
Flusberg et al. “In Vivo Brain Imaging Using a Portable 3.9 Gram Two-photon Fluorescence Microendoscope”, Optics Letters 30(17), 2272-2274 (Sep. 2005).
Fu et al. “Integration of a Double-clad Photonic Crystal Fiber, a GRIN lens and a MEMS mirror for nonlinear optical endoscopy.” BIO Meeting, Fort Lauderdale (Mar. 19, 2006).
Fu et al. “Nonlinear optical endoscopy based on a double clad photonic crystal fiber and a MEMS mirror.” Optics Express 14, No. 3, 1027-1032 (Feb. 2006).
Gonzalez RV et al. “A real-time EMG-driven virtual arm.” Comput. Biol. Med. 32(1) 25-26 (Jan. 2002) Abstract Only.
Helmchen et al. “Deep Tissue two-photon microscopy.” Nature Methods 2(12), 932-940 (Dec. 2005).
Jung et al. “In vivo mammalian brain imaging using one- and two-photon fluorescence microendoscopy.” J. Neurophysiol. 92, 3121-3133 (May 2004).
Jung et al. “Multiphoton endoscopy.” Optics Letters 28(11), 902-904 (Jun. 2003).
Konig et al. “High-resolution multiphoton tomography of human skin with subcellular spatial resolution and picosecond time resolution.” Society of Photo-Optical Instrum. Engineers (2003) Abstract Only.
Lee et al. “Integrated semiconductor optical sensor for chronic, minimally-invasive imaging of brain functions.” Proceedings of the 28thIEEE, 1025-1028 (Aug.-Sep. 2006).
Leven et al. “In vivo multiphoton microscopy of deep brain tissue.” J. Neurophysiol. 91, 1908-1912 (Dec. 2003).
Lieber et al. “Biomechanical properties of the brachioradialis muscle: Implications for surgical tendon transfer.” The Journal of Hand Surgery 30A(2), 273-282 (Mar. 2005).
Mertz. “Nonlinear microscopy: New techniques and applications.” Current Opinion in Neurobiology 14, 610-616 (2004).
Messerschmidt et al. “Novel concept of GRIN optical systems for high resolution microendoscopy. Part 1: Physical aspects.” Proc. Of SPIE 6432, 643202-1-643202-9 (2007).
Monfared et al. In Vivo Imaging of Mammalian Cochlear Blood Flow Using Fluorescence Microendoscope. Otology and Neurotology 27, 144-152 (2006).
Niell et al. “Live Optical Imaging of Nervous System Development.” Annu. Rev. Physiol. 66, 771-798 and C1-05 (2004).
Nucciotti et al. “Functional imaging of muscle cells by Second Harmonic Generation.” Proc. Of SPIE 6089, 608911-1-608911-8 (2006).
“Imaging and Optical technology at Aberdeen.” Optics and Laser Technology 25(6), 399-405 (1993).
Panchangam et al. “A novel optical imaging system for investigating sarcomere dynamics in single skeletal muscle fibers.” Proc. Of SPIE 6088, 608808-1-608808-11 (2006).
Plotnikov et al. “Characterization of the Myosin-based source for Second-Harmonic Generation from muscle sarcomeres.” Biophysical Journal 90, 693-703 (Jan. 2006).
Plotnikov. “Measurement of muscle disease by quantitative second-harmonic generation imaging.” J. Biomed. Opt. 13 (Aug. 2008) Abstract Only.
Ponten et al. “Intraoperative muscle measurements reveal a relationship between contracture formation and muscle remodeling.” Muscle & Nerve 36, 47-54 (Jul. 2007).
Rothstein et al. “Multi-photon excitation microscopy in intact animals.” Journal of Microscopy 22(Pt. 1), 58-64 (2006).
Rothstein et al. “Skeletal Muscle NAD(P)H Two-photon fluorescence microscopy in vivo: Topology and Optical inner filters.” Biophysical Journal 88, 2165-2176 (Mar. 2005).
Schenkl et al. “Applications of rigid and flexible GRIN-endoscopes.” Proc. Of SPIE 6433, 64330N-1-64330N-7 (2007).
Shaw et al. “Infrared spectroscopy of dystrophic mdx mouse muscle tissue distinguishes among treatment groups.” J. Applied Physiol. 81, 2328-2335 1996).
Zipfel et al. “Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation.” PNAS 100(12), 7075-7080 (Jun. 2003).
Boulesteix et al. “Second-harmonic Microscopy of Unstained Living Cardiac Myocytes: Measurements of sarcomere length with 20-nm accuracy.” Optics Letters 29(17), 2031-2033 (Sep. 1, 2004).
Campagnola et al. “Three-Dimensional High-Resolution Second-Harmonic Generation Imaging of Endogenous Structural Proteins in Biological Tissues.” Biophysical Journal 81, 493-508 (Jan. 2002).
Campagnola et al. “Nonlinear Optical Spectroscopy.” Optics & Photonics News, 40-45 (Jun. 2003).
Chu et al. “Studies of X(2)/X(3)Tensors in Submicron-Scaled Bio-Tissues by Polarization Harmonics Optical Microscopy.” Biophysical Journal 86, 3914-3922 (Jun. 2004).
Freund et al. &#

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method and system of using intrinsic-based photosensing with... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and system of using intrinsic-based photosensing with..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and system of using intrinsic-based photosensing with... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4274260

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.