Surgery – Miscellaneous – Methods
Patent
1994-08-16
1997-12-09
Lacyk, John P.
Surgery
Miscellaneous
Methods
36441301, 540455, A61B 1700
Patent
active
056949502
ABSTRACT:
A method and system for use in treating a patient with an immunosuppressant to prevent an adverse immune response, either a rejection of a transplanted organ or an attack on the patient's body by its own immune system caused by an autoimmune disease, without unduly suppressing the ability of the patient's immune system to combat infection. The method employs an expert system to provide non-numerical information concerning the course of action to be taken with respect to a patient's immunosuppressant treatment, at a given time, including, in particular, an instruction on whether the immunosuppressant dosage being administered to the patient should be changed, and if so how. That instruction is determined by the expert system through analysis of standardized characterizations assigned to standardized patient examination criteria including levels of the immunosuppressant in blood plasma and whole blood. The method also employs a means for determining the actual numerical immunosuppressant dosage the patient should receive at a given time.
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patent: 5019974 (1991-05-01), Beckers et al.
patent: 5365948 (1994-11-01), McMichael
Transplantation Proceedings, vol. XXIII, No. 6, Dec. 1991 (Appleton & Lange) (specifically, see the two articles below).
J. McMichael et al., Evaluation of a Novel "Intelligent" Dosing System for Optimizing FK 506 Therapy, Transplantation Proceedings, vol. XXIII No. 6, Dec. 1991, pp. 2780-2782.
G.J.V. Nossal, Summary of the First International FK 506 Congress: Perspectives and Prospects, Transplantation Proceedings, vol. XXIII No. 6, Dec. 1991, pp. 3371-3375.
Slides presented by John McMichael during a speech at the First International Congress on FK 506 on Aug. 21, 1991 at the University of Pittsburgh Medical Center (reported in the Transplantation Proceedings, vol. XXIII, No. 6, Dec. 1991).
Leslie Bendra Sabbagh, `Intelligent` Dosing System Optimizes Drug Therapy, The Medical Post. Sep. 17, 1991, p. 26 (The Medical Post is published in Toronto, Ontario, Canada).
Abbottbase.TM. Aminoglycosides Demonstration Program Operations Manual, Version 2.00 (and Software (not included)), by Abbott Diagnostics, Aug. 1988.
J & W McMichael Software Inc.
Lacyk John P.
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