Method and system for the controlled release of biologically act

Details Method and system for the controlled release of biologically act Method and system for the controlled release of biologically act

1981-06-29

1984-09-04

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

A61K 3726

Patent

active

044696817

ABSTRACT:
A process and system for controlled delivery of a biologically active substance to an animal body fluid which comprises contacting fluid with a reversible complex of a conjugate (1) and a binding macromolecule (2), wherein the conjugate (1) comprises a biologically active portion which is intended to be proportionately released into a body fluid stream in response to varying concentration levels of a component of the body fluid stream, and a complexing substrate portion which conjugates with the biologically active portion and which is characterized by affinity to the binding macromolecule (2), competitivey or non-competitively with the variable component of the body fluid; thereby causing the component present in the body fluid to complex to the binding macromolecule and thus releasing the conjugate (1) therefrom into the fluid.
The process and system are particularly applicable for the glucose-controlled release of insulin and other hypoglycemic agents in the treatment of diabetes.

REFERENCES:
patent: 3549409 (1970-12-01), Dyck
patent: 3673612 (1972-07-01), Merrill et al.
patent: 3847890 (1974-11-01), Green et al.
patent: 3857393 (1974-12-01), Rose
patent: 4003792 (1977-01-01), Mill et al.
patent: 4239664 (1980-12-01), Teng
Biological Chemistry, 2nd ed., pp. 295-298, (1971).
Chemical Abstracts, 88:187858t (1978).
Chemical Abstracts, 87:115291j (1977).
Chemical Abstracts, 79:39405s (1973).
Separation News--Pharmacia Fine Chemicals, 3, 1979, "Affinity Chromatography of Some Plasma Proteins and Membrane Glycoproteins".
Gray, Arch. Biocyem. Biophys. 163, 426, (1974).
Cerami et al., "Role of Nonenzymatic Glycosylation in the Development of the Sequelae of Diabetes Mellitus," Metabolish, 28:431-437, (1979).
Brownlee et al., "A Glucose-Controlled Insulin Delivery System: Semisynthetic Insulin Bound to Lectin", Science, 206:1190-1191, (1979).
Monnier et al., "Maillard Reactions Involving Proteins and Carbohydrates in vivo: Relevance to Diabetes Mellitus and Aging", Prog. Fd. Nutr. Sci., 5:315-327, (1981).
Brownlee et al., "Measurement of Glycosylated Amino Acids and Peptides from Urine of Diabetic Patients Using Affinity Chromatography", Diabetes, 29:1044-1047, (1980).
Brownlee et al., "The Biochemistry of the Complications of Diabetes Mellitus", Ann. Rev. Biochem., 50:385-432, (1981).
Technology Review, vol. 81, #7, Jun., Jul. 1979.
Wall Street Journal, May 25, 1979.
J. Biol. Chem. 253, 2070, (1978).
J. Biol. Chem., 252, 7678, (1977).

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