Method and system for the controlled release of biologically act

Details Method and system for the controlled release of biologically act Method and system for the controlled release of biologically act

1979-07-31

1982-09-07

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

2601127, A61K 3726, C07C10352

Patent

active

043483879

ABSTRACT:
A process and system for controlled delivery of a biologically active substance to an animal body fluid which comprises contacting fluid with a reversible complex of a conjugate (1) and a binding macromolecule (2), wherein the conjugate (1) comprises a biologically active portion which is intended to be proportionately released into a body fluid stream in response to varying concentration levels of a component of the body fluid stream, and a complexing substrate portion which conjugates with the biologically active portion and which is characterized by affinity to the binding macromolecule (2), competitively or non-competitively with the variable component of the body fluid; thereby causing the component present in the body fluid to complex to the binding macromolecule and thus releasing the conjugate (1) therefrom into the fluid.
The process and system are particularly applicable for the glucose-controlled release of insulin and other hypoglycemic agents in the treatment of diabetes.

REFERENCES:
patent: 3847890 (1974-11-01), Green et al.
patent: 4003792 (1977-01-01), Mill et al.
Technology Review, vol. 81, #7, Jun., Jul. 1979.
Wall Street Journal, May 25, 1979.
J. Biol. Chem., 253, 2070, (1978).
J. Biol. Chem., 252, 7678, (1977).
Gray, Arch. Biochem. Biophys., 163, 426, (1974).

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