Method and system for predicting gene pathway using gene...

Details Method and system for predicting gene pathway using gene... Method and system for predicting gene pathway using gene...

2005-12-07

2010-12-07

Lin, Jerry (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

Reexamination Certificate

active

07848890

ABSTRACT:
Provided are a method and system for predicting pathways of genes that serve the same biological purpose using gene expression pattern data and protein interaction data. The method of predicting a gene pathway includes: a first step of generating partial pathways from gene expression pattern data by using a pathway extraction algorithm, and matching the partial pathways to express them as a graph; a second step of generating partial pathways from protein interaction data by using a pathway extraction algorithm, and matching the partial pathways to express them as a graph; and a third step of combining a graph made in the first step and a graph made in the second step by using a graph matching algorithm to make a combined graph.

REFERENCES:
patent: 1020030071225 (2003-09-01), None
E. Segal et al., “Discovering molecular pathways from protein interaction and gene expression data”, Bioinformatics 19(1), © Oxford University Press 2003, vol. 19 Suppl 1, 2003, pp. 1264-1272, DOI: 10. 1093/bioinformatics/btg 1037.
N. Przulj et al., “Functional topology in a network of protein interactions”, Bioinformatics 20(3), © Oxford University Press 2004, vol. 20 No. 3, 2004, pp. 340-348, DOI: 10. 1093/bioinformatics/btg 415.

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