Method and system for morphology based mitosis...

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C128S922000, C382S133000, C702S020000, C703S011000

Reexamination Certificate

active

07979212

ABSTRACT:
A method and system for morphology based mitosis identification and classification of digital images. Luminance parameters such as intensity, etc. from a digital image of a biological sample (e.g., tissue cells) to which a chemical compound (e.g., a marker dye) has been applied are analyzed and corrected if necessary. Morphological parameters (e.g., size, elongation ratio, parallelism, boundary roughness, convex hull shape, etc.) from individual components within the biological sample are analyzed. A medical conclusion (e.g., type and count of mitotic cells) or a life science and biotechnology experiment conclusion is determined from the analyzed luminance and morphological parameters. The method and system may be used to develop applications for automatically obtaining a medical diagnosis (e.g., a carcinoma diagnosis).

REFERENCES:
patent: 4724543 (1988-02-01), Klevecz
patent: 5018209 (1991-05-01), Bacus
patent: 5526258 (1996-06-01), Bacus
patent: 5544650 (1996-08-01), Boon et al.
patent: 5546323 (1996-08-01), Bacus et al.
patent: 6009342 (1999-12-01), Brasch et al.
patent: 6151405 (2000-11-01), Douglass
patent: 6215892 (2001-04-01), Douglass
patent: 6330349 (2001-12-01), Hays
patent: 6365362 (2002-04-01), Terstappen
patent: 6404916 (2002-06-01), de la Torre-Bueno
patent: 6418236 (2002-07-01), Ellis
patent: 6445817 (2002-09-01), de la Torre-Bueno
patent: 6479493 (2002-11-01), Whitehead et al.
patent: 6518554 (2003-02-01), Zhang
patent: 6546123 (2003-04-01), McLaren
patent: 6553135 (2003-04-01), Douglass
patent: 6605342 (2003-08-01), Burghaus et al.
patent: 6631203 (2003-10-01), Ellis
patent: 6645731 (2003-11-01), Terstappen
patent: 6671393 (2003-12-01), Hays
patent: 6674881 (2004-01-01), Bacus
patent: 6674884 (2004-01-01), Bacus et al.
patent: 6674896 (2004-01-01), de la Torre-Bueno
patent: 6697509 (2004-02-01), de la Torre-Bueno
patent: 6711283 (2004-03-01), Soenksen
patent: 6718053 (2004-04-01), Ellis
patent: 6768511 (2004-07-01), Nakai
patent: 6775402 (2004-08-01), Bacus
patent: 6800249 (2004-10-01), de la Torre-Bueno
patent: 6900426 (2005-05-01), Zhang
patent: 6911315 (2005-06-01), Rimm
patent: 6914613 (2005-07-01), Marchand
patent: 6917696 (2005-07-01), Soenksen
patent: 6920239 (2005-07-01), Douglass
patent: 2002/0009759 (2002-01-01), Terstappen
patent: 2002/0061542 (2002-05-01), Rimm
patent: 2002/0168657 (2002-11-01), Chen
patent: 2002/0172987 (2002-11-01), Terstappen
patent: 2003/0045451 (2003-03-01), Bacus
patent: 2003/0049701 (2003-03-01), Muraca
patent: 2003/0068626 (2003-04-01), Wang
patent: 2003/0073096 (2003-04-01), Bao
patent: 2003/0092047 (2003-05-01), LaMorte et al.
patent: 2003/0096261 (2003-05-01), Fruehauf
patent: 2003/0129676 (2003-07-01), Terstappen
patent: 2003/0165263 (2003-09-01), Hamer
patent: 2003/0168577 (2003-09-01), Zhang
patent: 2003/0170703 (2003-09-01), Piper
patent: 2003/0215936 (2003-11-01), Kallioniemi
patent: 2003/0231791 (2003-12-01), de la Torre-Bueno
patent: 2004/0004614 (2004-01-01), Bacus
patent: 2004/0009098 (2004-01-01), de la Torre-Bueno
patent: 2004/0066960 (2004-04-01), McLaren
patent: 2004/0071327 (2004-04-01), Ellis
patent: 2004/0081345 (2004-04-01), Douglass
patent: 2004/0085443 (2004-05-01), Kallioniemi
patent: 2004/0115692 (2004-06-01), Linder
patent: 2004/0136582 (2004-07-01), Bacus
patent: 2004/0141637 (2004-07-01), Bacus
patent: 2004/0167806 (2004-08-01), Eichhorn
patent: 2004/0169883 (2004-09-01), Eichhorn
patent: 2004/0170325 (2004-09-01), Eichhorn
patent: 2004/0171036 (2004-09-01), Wang
patent: 2004/0171091 (2004-09-01), Lesko
patent: 2004/0176277 (2004-09-01), Sowadski
patent: 2004/0176372 (2004-09-01), Suto
patent: 2004/0180889 (2004-09-01), Suto
patent: 2004/0191854 (2004-09-01), Lapen
patent: 2004/1017031 (2004-09-01), Soenksen
patent: 2004/0202357 (2004-10-01), Perz
patent: 2004/0210547 (2004-10-01), Wentland
patent: 2004/0214872 (2004-10-01), Suto
patent: 2004/0236773 (2004-11-01), Bacus
patent: 2004/0252875 (2004-12-01), Crandall
patent: 2004/0256538 (2004-12-01), Olson
patent: 2005/0003464 (2005-01-01), Tibbe
patent: 2005/0004024 (2005-01-01), Tibbitts
patent: 2005/0037406 (2005-02-01), de la Torre-Bueno
patent: 2005/0069900 (2005-03-01), Lentrichia
patent: 2005/0070020 (2005-03-01), Klautky
patent: 2005/0136493 (2005-06-01), Rubin
patent: 2005/0136509 (2005-06-01), Gholap
patent: 2005/0136549 (2005-06-01), Gholap et al.
patent: 2005/0181463 (2005-08-01), Rao
patent: 2006/0014238 (2006-01-01), Gholap et al.
patent: 0283255 (1988-09-01), None
patent: 2000/224595 (2000-08-01), None
patent: WO 03/105675 (2003-12-01), None
Albert, et al. New method of nuclear grading of tissue sections by means of digital image analysis with prognostic significance for node-negative breast cancer patients. Cytometry. 1996; 24(2):140-50.
Comaniciu, et al. image-guided decision support system for pathology. Machine Vision and Applications. Springer, Verlag, DE. 1999; 11(4): 213-224.
Drezet, et al. Automatic mitotic index estimation for the prognostication of breast cancer from histology images. IEE Colloquium Intelligent Methods in Healthcare and Medical Applications. Oct. 20, 1998. pp. 14-1.
Gao, et al. Computer-aided prostrate cancer diagnosis using image enhancement and JPEG 2000. Proceedings-SPIE the International Society for Optical Eng. International Society for Optical Engineering; Applications of Digital Image Processing XXVI. 2003; 5203;323-334.
Hatanaka, et al. Quantitative immunohistochemical evaluation of HER2
eu expression with HercepTestTM in breast carcinoma by image analysis. Pathol Int. 2001; 51(1):33-6.
Kate, et al. Method for counting mitoses by image processing in Feulgen stained breast cancer sections. Cytometry. 1993;14(3):241-50.
Krtolica, et al. Quantification of epithelial cells in coculture with fibroblasts by fluorescence image analysis. Cytometry. 2002; 49(2):73-82.
Madachy, et al. Image analysis for automatic classification of miotic cervical cells. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Nov. 4, 1988. pp. 372-374.
Rodenacker, et al. A feature set for cytometry on digitized microscopic images. Anal Cell Pathol. 2003; 25(1):1-36.
Sunbland, et al. The use of image analysis and automation for measuring mitotic index in apical conifer rneristems. Journal of Experimental Botany. 1998; 49:1749-1756.
Van Der Laak, et al. Development and validation of a computerized cytomorphometric method to assess the maturation of vaginal epithelial cells. Cytometry. 1999; 35(3):196-202.
Weyn, et al. Automated breast tumor diagnosis and grading based on wavelet chromatin texture description. Cytometry. 1998; 33(1):32-40.
Gallart Biotech. Monoclonal Antibody Index. vol. 1: cancer. Available at: http://www.gallartinternet.com/mai. Accessed on Aug. 4, 2008.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method and system for morphology based mitosis... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and system for morphology based mitosis..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and system for morphology based mitosis... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2649601

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.