Electricity: measuring and testing – Particle precession resonance – Using a nuclear resonance spectrometer system
Patent
1995-08-07
1996-07-23
O'Shea, Sandra L.
Electricity: measuring and testing
Particle precession resonance
Using a nuclear resonance spectrometer system
324309, G01R 3320
Patent
active
055393101
ABSTRACT:
A method and system for measuring the effective diffusion tensor for spin labeled particles, and generating images therefrom. The effective diffusion tensor is related to the echo intensity in an NMR spin-echo experiment. This relationship is used to design experiments from which the diffusion tensor components are estimated. Estimation of Deff provides the theoretical basis for a new MRI modality, diffusion tensor imaging. Diffusion ellipsoids may be used for generating images representative of physical characteristics of the observed object. Scalar invariants of the diffusion tensor are also used for imaging.
REFERENCES:
patent: Re33391 (1990-10-01), Breton et al.
patent: 4719423 (1988-01-01), Vinegar et al.
patent: 4780674 (1988-10-01), Breton et al.
patent: 4809701 (1989-03-01), Le Bihan et al.
patent: 4914608 (1990-03-01), Le Bihan et al.
patent: 5065097 (1991-11-01), Nozokido et al.
patent: 5092335 (1992-03-01), Le Bihan
patent: 5235276 (1993-08-01), Lew
patent: 5317262 (1994-05-01), Moonen et al.
"Molecular Diffusion Nuclear Magnetic Resonance Imaging", Magnetic Resonance Quarterly, vol. 7, No. 1, pp. 1-30, 1991, D. LeBihan.
"Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient"; J. Chem. Physics, vol. 42, No. 1, pp. 288-292, 1965, E. O. Stejskal, J. E. Tanner.
"Use of Spin-Echoes in a Pulsed Magnetic Field Gradient to Study Anisotropic, Restricted Diffusion and Flow", J. Chem. Physics, vol. 43, No. 10, pp. 3597-3603, 1965, E. O. Stejskal.
Thomas C. Farrar and Edwin D. Becker Pulse and Fourier Transform NMR, Introduction to Theory and Methods, Chapter 7, pp. 100-110 (1971).
Wesley T. Huntress, Jr., A Nuclear Resonance Study of Anisotropic Molecular Rotation in Liquid Chloroform and in Chloroform-Benzene Solution, NMR Study of Anisotropic Molecular Rotation, vol. 75, pp. 103-111 No. 1 (Jan. 1969).
G. G. Cleveland, D. C. Chang, C. F. Hazlewood and H. E. Rorschach, Nuclear Magnetic Resonance Measurement of Skeletal Muscle, Biophysical Journal, vol. 16, pp. 1043-1053 (1976).
Phillipe Douek, Robert Turner, James Pekar, Nicholas Patronas and Denis LeBihan, MR Color Mapping of Myeline Fiber Orientation, Journal of Computer Assisted Tomograph 15(6)-923-929, Nov.-Dec. (1991).
L. Garrido, U. M. Spencer, K. K. Kwong, V. J. Wedeen, HL Kantor, Molecular diffusion to determine muscle fiber ] orientation: in vitro studies in perfused hearts. Presented at the 10th Annual Meeting of the Society of Magnetic Resonance in Medicien; Aug. 10-16, 1991, San Francisco, CA.
P. J. Basser, D. LeBihan, 1992, Fiber orientation mapping in an anisotropic medium and NMR diffusion spectroscopy, PRoc. SMRM, Berline, 1:1221, Aug. 8, 1992.
P. J. Basser, J. Mattiello, D. LeBihan, Aug., 1992, Diagonal and off-diagonal components of the self-diffusion tensor; their relation to and estimation from the NMR spin-echo, Proc. SMRM, Berline, 1:1222, Aug. 8, 1994-2.
Basser Peter J.
LeBihan Denis
Mattiello James H.
Mah Raymond
O'Shea Sandra L.
The United States of America as represented by the Department of
LandOfFree
Method and system for measuring the diffusion tensor and for dif does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and system for measuring the diffusion tensor and for dif, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and system for measuring the diffusion tensor and for dif will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-715495