Radiant energy – Ionic separation or analysis – With sample supply means
Reexamination Certificate
2005-08-16
2005-08-16
Lee, John R. (Department: 2881)
Radiant energy
Ionic separation or analysis
With sample supply means
C250S281000, C250S282000, C250S287000
Reexamination Certificate
active
06930305
ABSTRACT:
A mass spectrometry quantitation technique enables high-throughput quantitation of small molecules using a laser-desorption (e.g., MALDI) ion source coupled to a triple-quadrupole mass analyzer. The ions generated from the ion source are collisionally damped/cooled, and then quantitatively analyzed using the triple-quadrupole analyzer operated in the multiple-reaction-monitoring (MRM) mode. Significantly improved measurement sensitivity is obtained by applying laser pulses to the ion source at a high pulse rate of about 500 Hz or higher. This allows the data acquisition to be performed rapidly, and the speed of about one second for each sample point on the ion source target has been achieved.
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Cohen et al., Anal. Bioanal. Chem., 373, 571-586 (2002).
Go et al., Anal. Chem., 75 (10), 2504-2506 (2003).
Go et al., Anal. Chem., 75 (20), 5475-5479 (2003).
Guo et al., Anal. Chem., 74 (7), 1637-1641 (2002).
Hatsis et al., Rapid Communications in Mass Spectrometry, 17, 2303-2309 (2003).
Hayes et al, Anal. Chem., 73 (6), 1292-1295 (2001).
Kinumi et al., Proceedings of the the 48thASMS Conference on Mass Spectrometry and Allied Topies (2000).
Leriche et al., Rapid Communications in Mass Spectrometry, 15, 608-614 (2001).
Lin et al., Anal. Chem., 74 (22), 5793-5798 (2002).
Reyzer et al., Journal of Mass Spectrometry, 38, 1081-1092 (2003).
Shen et al., Anal. Chem., 73 (3), 612-619 (2001).
Wei et al., Nature, 399, 243-246 (1999).
Corr John J.
Covey Thomas R.
Fisher William H.
Tung Chau
Fernandez Kalimah
Lee John R.
MDS Inc.
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