Method and system for growing molluscum contagiosum in xenograft

Details Method and system for growing molluscum contagiosum in xenograft Method and system for growing molluscum contagiosum in xenograft

1996-08-20

1999-03-23

Scheiner, Laurie

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

435239, 424 931, 4242041, 4242321, C12N 700, C12N 702, A61K 39275, A61K 3912

Patent

active

058858229

ABSTRACT:
A method and system is provided for the growth of the molluscum contagiosum virus in human skin xenografted to an immunocompromised host. A human skin graft is infected with molluscum contagiosum virus attached to or beneath a skin section of the immunocompromised host. According to the method, a section of skin of an immunocompromised host is prepared for receiving a human skin xenograft which is then placed onto or into the host. The human skin is infected with the molluscum contagiosum virus. The animals are monitored and the newly grown virus and its products are harvested for further study.

REFERENCES:
Epstein, Seminars in Dermatology, vol. 3 184-189 (1992).
Brune, et al., The Society for Investigative Dermatology, Inc., pp. 277-281 (1995).
Buller, et al., "Replication of Molluscum Contagiosum Virus", Virology, vol. 213, pp. 555-669 (1995).
W. Bonnez, et al., "Growth of Molluscum Contagiosum (MC) Virus (V) in a Human Foreskin Xenograft-Severe Combined Immunodeficiency (SCID) Mouse Model", University of Rochester Sch. of Med. and Dent., Rochester, NY 14642 (Abstract).
McFaddeen G, Pace W, Purres J, Dales S; Biogenesis of Poxviruses:Transitory expression of M.contagiosum early functions; Virol. 94 297-313 1979.
Kreider J,Howlett M,Lill N, Barlett G, Zainoo R, Sedlacek T, Mortel R In vivo transformation of human skin with human papillomavirus type 11 from condylomata acuminata; J. Virol. 59(2). 1986.
Sterling J,Stanley M, Gatward G,Minson T Production of human papilloma type16 virions in a keratinocyte cell line J. Virol. 64(12) 6305-6307. 1990.
Bonnez W,Rose R,Da Rin C,Borkuis C,DeMesy Jensen K,Reichman R Propagation of human papillomavirus type 11 in human xenografts using the severe combined immunodeficiency (SCID) mouse and comparison to the nude mouse model Virol 197 455-458. 1993.
DiLoreto D,Epstein L,Lazar E,Britt W,Del Cerro M, Methods in laboratory investigation Cytomegalovirus infection of human retinal tissue:An in vivo model Lab. Invest. 71(1) 141-148. 1994.
Postlethwaite R., Molluscum Conagiosum: A Review, Arch. Environ. Health 1979, 21:432-452.

Affiliated with

Also associated with

Rating

Method and system for growing molluscum contagiosum in xenograft does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and system for growing molluscum contagiosum in xenograft, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and system for growing molluscum contagiosum in xenograft will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2124218