Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-06-17
1996-12-03
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 243, 536 2433, 382128, 382129, 382199, 382279, C12Q 168, C12P 1934, C07H 2104, G06K 1108
Patent
active
055807283
ABSTRACT:
The present invention pertains to a process which can be fully automated for accurately determining the alleles of STR genetic markers. More specifically, the present invention is related to performing PCR amplification on a location of DNA, labelling the PCR products, converting the labels into a signal, removing a reproducible PCR stutter pattern from the signal by means of a computational device, and then determining the genotype of the location of the DNA. The invention also pertains to genetics applications and systems which can effectively use this genotyping information.
REFERENCES:
patent: 5161204 (1992-11-01), Hutcheson et al.
patent: 5273632 (1993-12-01), Stockham et al.
Schwartz et al, "Fluorescent multiplex linkage analysis and carrier detection for Duchenne/Becker Muscular dystrophy" Am. J. Human Genetics 51:721-729, 1992.
McConkey, E. H. Human Genetics, The Molecular Revolution Jones and Bartlett Publishers, 1993, pp. 92-112.
Jones W. Gary
Rees Dianne
Schwartz Ansel M.
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