Chemistry: physical processes
Patent
1978-09-21
1980-02-12
Krizmanich, George H.
Chemistry: physical processes
233 26, 128214D, B04B 1512
Patent
active
041879791
ABSTRACT:
The method, and system for carrying out the steps of the method, are utilized in taking whole blood from a supply of blood withdrawn from a donor or from a previously banked supply of whole blood in a container, centrifuging the blood in a centrifuge device to separate the whole blood into its components, and then collecting the components, namely red blood cells, white blood cells, platelets and plasma. The fractionation of the whole blood in the centrifuge device takes place in first, second and third separation chambers. The first chamber has a square shape and is positioned in the centrifuge device in a diamond position. Each corner of the first separation chamber has an opening. Whole blood is pumped into one side corner opening and red blood cells are withdrawn from the other side corner opening and returned to the container for recirculation through the first chamber. White blood cells, platelets and plasma are withdrawn from the upper corner opening and passed through the second chamber wherein white blood cells are separated by centrifugal force. The plasma and platelets are then withdrawn from the second chamber and passed through the third chamber wherein the platelets are separated from the plasma by centrifugal force. The plasma exiting from the third separation chamber is passed back into the bottom corner of the first chamber to cause a flow of plasma across the flow of whole blood and red blood cells to elute white blood cells and plateletstherefrom and to wash the red blood cells. By appropriate operation of electromechanically controlled clamps associated with tubing carrying the various blood components, plasma can be siphoned off into a plasma collection receptacle located outside the centrifuge device. After the red blood cells have been recirculated several times through the first separation chamber, the red blood cells then can be directed to a red blood cell collection receptacle by operation of other electromechanically controlled clamps.
REFERENCES:
patent: 3655123 (1972-04-01), Judson et al.
patent: 3967777 (1976-07-01), Canevari
patent: 3982691 (1976-09-01), Schlutz
patent: 4091989 (1978-05-01), Schlutz
Cullis Herbert M.
De Vries James H.
Dorsey Evelyn E.
Baxter Travenol Laboratories Inc.
Collins Henry W.
Flattery Paul
Krizmanich George H.
Vigil Thomas R.
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