Surgery – Diagnostic testing – Cardiovascular
Reexamination Certificate
2006-10-17
2006-10-17
Pezzuto, Robert E. (Department: 3766)
Surgery
Diagnostic testing
Cardiovascular
C600S515000, C600S517000, C600S519000, C600S521000
Reexamination Certificate
active
07123953
ABSTRACT:
A method of assessing the cardiac arrhythmia risk in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. In one embodiment, the method comprises the steps of: (a) collecting at least one QT and RR interval data set from the subject; (b) separating fluctuations from slow trends in said at least one QT and RR interval data set; (c) comparing said QT and RR fluctuations to one another and (d) generating from the comparison of step (c) partial measures of risk of cardiac arrhythmia in said subject. A greater difference between QT and RR fluctuations indicates greater risk of cardiac arrhythmia in said subject. The data sets are collected in such a manner that they reflect almost exclusively the conduction in the heart muscle and minimize the effect on the data sets of rapid transients due to autonomic nervous system and hormonal control.
REFERENCES:
patent: 4870974 (1989-10-01), Wang
patent: 5020540 (1991-06-01), Chamoun
patent: 5117834 (1992-06-01), Kroll et al.
patent: 5148812 (1992-09-01), Verrier et al.
patent: 5323783 (1994-06-01), Henkin et al.
patent: 5419338 (1995-05-01), Sarma et al.
patent: 5560370 (1996-10-01), Verrier et al.
patent: 5713367 (1998-02-01), Arnold et al.
patent: 5792065 (1998-08-01), Xue et al.
patent: 5794623 (1998-08-01), Forbes
patent: 5827195 (1998-10-01), Lander
patent: 5842997 (1998-12-01), Verrier et al.
patent: 5891047 (1999-04-01), Lander et al.
patent: 5921940 (1999-07-01), Verrier et al.
patent: 5951484 (1999-09-01), Hoium et al.
patent: 6361503 (2002-03-01), Starobin et al.
Arnold et al.;The dependence on heart rate of the human ventricular action potential duration, Cardiovascular Research, 16, 547-551 (1982).
Chernyak et al.;Class of Exactly Solvable Models of Excitable Media, Phys. Rev. Lett,. 80:25, 5675-5678 (1998).
Chernyak et al.;Where do dispersion curves end? A basic question in theory of excitable media, Phys. Rev. E,. 58:4, 4108-4111 (1998).
Ciavolella et al.;Exponential Fit of QT Interval-Heart Rate Relation During Exercise Used to Diagnose Stress-induced Myocardinal Ischemia, Journal of Electrocardiology, 24:2, 145-153 (1991).
Cole et al.;Heart-Rate Recovery Immediately After Exercise As A Predictor Of Mortality, The New England Journal of Medicine, 341:18, 1351-1357 (Oct. 1999).
Franz et al.;Cycle Length Dependence of Human Action Potential Duration In Vivo: Effects of Single Extrastimuli, Sudden Sustained Rate Acceleration and Deceleration, and Different Steady-State Frequencies, J. Clin. Invest,. 82, 972-979 (1988).
Froelicher, Jr. et al.;A comparison of three maximal treadmill exercise protocols, Journal of Applied Physiology, 36:6, 720-725 (1974).
Hintze et al.;Prognostic Properties of QT/RR Dynamics in Survivors of Myocardial Infarction with Reduced Systolic Function, NASPE Annual Meeting, Washington, D.C. (May 17-20, 2000).
Jonnalegedda et al.;An Exponential Formula for Heart Rate Dependence of QT Interval During Exercise and Cardiac Pacing in Humans: Reevaluation of Bazett's Formula, Am J Cardiol, 54, 103-108 (1984).
Jonnalegedda et al.;Hysteresis in the Human RR-QT Relationship During Exercise and Recovery, PACE10, 485-491 (1997).
Krahn, M.D. et al.;Hysteresis of the RT Interval With Exercise; A New Marker for the Long-QT Syndrome?, Circulation, 96, 1551-1556 (1997).
Lau et al.;Hysteresis of the ventricular paced QT interval in response to abrupt changes in pacing rate, Cardiovascular Research, 22, 67-72 (1988).
Starobin et al.;The role of a critical excitation length scale in dynamics of reentrant cardiac arrhythmias, Herzschr Elektrophys, 10, 119-136 (Month Unknown, 1999).
Surawicz;Will QT Dispersion Play a Role in Clinical Decision-Making?, J Cardiovascular Electrophysiol, 7, 777-784 (1996).
Swan et al.;Rate adaption of QT intervals during and after exercise in children with congenital long QT syndrome, European Heart Journal, 19, 508-513 (1998).
Takahashi et al.;Paradoxically Shortened QT Interval after a Prolonged Pause, PACE, 21, 1476-1479 (1998).
Pierpoint et al.;Heart rate recovery post-exercise as an index of parasympathetic activity, Journal of the Autonomic Nervous System, 80, 169-174 (May 12, 2000).
Chernyak Yuri B.
Starobin Joseph M.
Heller Tammie K.
Mediwave Star Technology Inc.
Myers Bigel & Sibley Sajovec, PA
Pezzuto Robert E.
LandOfFree
Method and system for evaluating arrhythmia risk with QT-RR... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and system for evaluating arrhythmia risk with QT-RR..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and system for evaluating arrhythmia risk with QT-RR... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3707787