Method and system for directional, enhanced fluorescence from mo

Details Method and system for directional, enhanced fluorescence from mo Method and system for directional, enhanced fluorescence from mo

1989-02-22

1991-04-09

Hannaher, Constantine

Radiant energy

Luminophor irradiation

250368, 2504591, 2504611, 2504831, 2504871, 436171, 436172, G01N 2162, G01N 2164

Patent

active

050067168

ABSTRACT:
Propagation modes within a corrugated optical waveguide are used to excite fluorescence from a layer of material which defines a wall of the waveguide. The fluorescence is emitted at discrete angles, which are a function of the wavelength and polarization of the emitted fluorescence. The intensity of fluorescence detected at the discrete angles of detection can approach 2000 times the intensity detected from the same fluorescence material coated on a glass slide. These features enable a number of tests to be performed simultaneously on an unknown sample, as well as providing a finer and more accurate determination of concentration of a substance over prior art systems.

REFERENCES:
patent: 4649280 (1987-03-01), Holland et al.
patent: 4804850 (1989-02-01), Norrish et al.
patent: 4882288 (1989-11-01), North et al.
"Wageguide mode enhancement of molecular fluorescence"-W. R. Holland and D. G. Hall, 1985, Optics Letters, vol. 10, pp. 414 to 416.
"Light emission from surface-plasmon and waveguide modes excited by N atoms near a silver grating"-Adams et al., Physical Review B, Condensed Matter, Third Series, vol. 25, No. 6, pp. 3457 to 3461.
"Thin grating couplers for integrated optics: an experimental and theoretical study"-Dalgoutte et al., Dec., 1975, vol. 14, No. 12, Applied Optics, pp. 2983 to 2998.
"Elastic scattering, absorption, and surface-enhanced Raman scattering by concentric spheres comprised of a metallic and a dielectric region"-Kerker et al., Physical Review B, vol. 26, No. 8, pp. 4052 to 4063, Oct. 15, 1982.

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