Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1983-06-13
1987-02-10
Rosen, Sam
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 4, 435 28, 436512, 436518, 436520, 436528, 436529, 436530, 436536, 436538, 436540, 436543, 436544, 436547, 436821, G01N 5300, G01N 33563
Patent
active
046422846
ABSTRACT:
A method and system for detecting and preferably measuring the presence of an activated complement complex in a sample is discussed. The presence of such an activated complex is indicative of complement pathway activation and includes a first complement component and a second complement component. The method uses a first binding agent specific to the first complement component and a second binding agent specific to the second complement component which when bound with the complex forms an aggregate. The second specific binding agent includes a label whose presence is used to detect and measure the amount of aggregate and therefore activated complex in a sample. An assay system and aggregate for use in an assay system are also discussed.
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Natelson et al.--Clinical Immunochemistry (1978) pp. 108-111 (Publisher Am. Assn. Clin. Chem.).
Harpel et al., Clinical Research 30:563A (1982).
Cooper et al., Springer Semin. Immunopathol. 6:195-212 (1983).
Chapter entitled "The Complement System" pp. 124-135 of Basic and Clinical Immunology. (4th ed. 1982).
Bergen et al., Molecular Immunology 19:857-864 (1982).
Chapter entitled "Laboratory Evaluation of Complement Activation" pp. 393-410 from Immunoassays: Clinical Laboratory Techniques for the 1980's (1980).
Hack et al., Journal of Immunology 127: 1450-1453 (1981).
Cooper Neil
Mayes James T.
Rosen Sam
Scripps Clinic and Research Foundation
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