Surgery – Diagnostic testing – Eye or testing by visual stimulus
Reexamination Certificate
2006-01-24
2006-01-24
Marmor, Charles (Department: 3736)
Surgery
Diagnostic testing
Eye or testing by visual stimulus
C356S484000
Reexamination Certificate
active
06988995
ABSTRACT:
A system for the in vivo detection of the effects of AD in the interior of an eye. A scanning polarimeter, including a residual retardance canceling system and an improved anterior segment retardance compensator, produces an optical analysis signal representing the birefringence of the retinal nerve fiber layer (RNFL) structures of the eye. The birefringence data is more accurate because of compensation for anterior segment birefringence and residual birefringence of optical components, such as, for example, the beam splitters, lenses, scanners and retarders. An electrical analysis signal representing a large (20 by 40 degrees) retardance map is produced and evaluated by an artificial neural network to produce an analysis classification signal representing the contribution of Alzheimer's disease to the birefringence of the retinal layer corresponding to the relationship of the electrical analysis signal to an analysis signal database.
REFERENCES:
patent: 5303709 (1994-04-01), Dreher et al.
patent: 5787890 (1998-08-01), Reiter et al.
patent: 6112114 (2000-08-01), Dreher
patent: 6137585 (2000-10-01), Hitzenberger et al.
patent: 6293674 (2001-09-01), Huang et al.
patent: 6356036 (2002-03-01), Zhou
patent: 6704588 (2004-03-01), Ansari et al.
Vapnik, Vladimir N., “An Overview of Statistical Learning Theory”IEEE Transactions on Neural Networks, vol. 10, No. 5, Sep. 1999.
Blanks, Janet C., Torigoe, Yasuhiro, Hinton, David R., and Blanks, Robert H.I., “Retinal Pathology in Alzheimer's Disease. I. Ganglion Cell Loss in Foveal/Parafoveal Retina”Neurobiology of Aging, vol. 17, No. 3, pp. 377-384 (1996).
Blanks, Janet C.; Schmidt, Susan Y.; Torigoe, Yasuhiro; Porrello, Kathryn V.; Hinton, David R. and Blanks, Robert H.I. “Retinal Pathology in Alzheimer's Disease. II. Regional Neuron Loss and Glial Changes in GCL”Neurobiology of Aging, vol. 17, No. 3, pp. 385-395 (1996).
Hedges III, Thomas R.; Galves, Rosalba Perez; Speigelman, Donna; Barbas, Nancy R.; Peli, Eli and Yardley, Christine J. “Retinal Nerve Fiber layer Abnormalities in Alzheimer's Disease”ACTA Ophthalmologica Scandinavica, 74:271-275 (1996).
Kergoat, Hélène; Kergoat, Marie-Jeanne; Justino, Lisette; Robillard, Alain; Bergman, Howard and Chertkow, Howard “Normal Optic Nerve Head Topography in the Early Stages of Dementia of the Alzheimer Type”Dementia and Geriatric Cognitive Disorders, 12:359-363 (2001).
Kergoat, Hélène; Kergoat, Marie-Jeanne; Justino, Lisette; Chertkow, Howard; Robillard, Alain; Bergman, Howard “An Evaluation of the Retinal Nerve Fiber Layer Thickness by Scanning Laser Polarimetry in Individuals with Dementia of the Alzheimer Type”ACTA Ophthalmologica Scandinavica79:187-191 (2001).
Moore John C.
Sinai Michael J.
Wong William
Zhou Qienyuan
Carl Zeiss Meditec Inc.
Marmor Charles
Smith Fangemonique
Stallman & Pollock LLP
LandOfFree
Method and system for detecting the effects of Alzheimer's... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and system for detecting the effects of Alzheimer's..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and system for detecting the effects of Alzheimer's... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3595303