Radiant energy – Ionic separation or analysis – With sample supply means
Reexamination Certificate
2007-01-16
2009-06-09
Berman, Jack I (Department: 2881)
Radiant energy
Ionic separation or analysis
With sample supply means
C250S281000, C250S282000, C250S425000, C250S42300F
Reexamination Certificate
active
07544933
ABSTRACT:
A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.
REFERENCES:
patent: 5580434 (1996-12-01), Robotti et al.
patent: 6787313 (2004-09-01), Morozov et al.
patent: 6818394 (2004-11-01), O'Donnell-Maloney et al.
patent: 6881588 (2005-04-01), Tegeler et al.
patent: 6911182 (2005-06-01), Tegeler et al.
patent: 6949741 (2005-09-01), Cody et al.
patent: 7015465 (2006-03-01), Karol et al.
patent: 2002/0092366 (2002-07-01), Brock et al.
patent: 2003/0228240 (2003-12-01), Dwyer
patent: 2004/0023410 (2004-02-01), Stacey
patent: 2004/0203175 (2004-10-01), Li et al.
patent: 2005/0029442 (2005-02-01), Takats et al.
patent: 2005/0230635 (2005-10-01), Takats et al.
patent: 2005/0242039 (2005-11-01), Wall
patent: 2006/0054805 (2006-03-01), Flanagan et al.
patent: 2006/0131497 (2006-06-01), Yang et al.
patent: 2006/0192107 (2006-08-01), DeVoe et al.
patent: 2006/0273254 (2006-12-01), Berkout et al.
patent: 2006/0289747 (2006-12-01), Schultz et al.
patent: 2007/0114386 (2007-05-01), Fischer et al.
patent: 2008/0054176 (2008-03-01), Hiraoka
patent: 2008/0135746 (2008-06-01), Wildgoose et al.
patent: WO 2005/104181 (2005-03-01), None
patent: WO 2005/017936 (2005-02-01), None
Takats et al. “Mass Spectrometry Sampling Under ambient Conditions with Desorption Electrospray Ionization”, Science, Oct. 15, 2004, vol. 306, pp. 471-473.
Cooks Robert G.
Cotte-Rodriguez Ismael
Gologan Bogdan
Takáts Zoltán
Wiseman Justin M.
Berman Jack I
Guterman Sonia K.
Ippolito Rausch Nicole
Lawson & Weitzen, LLP
Purdue Research Foundation
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