Method and system for allowing increased migration across a lipi

Details Method and system for allowing increased migration across a lipi Method and system for allowing increased migration across a lipi

1992-01-08

1994-02-08

Spear, Frank

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210649, 264 41, 264 43, B01D 6138

Patent

active

052845885

ABSTRACT:
A method and system are disclosed for allowing significantly increased migration of a molecule across a lipid bilayer membrane. The method includes combining an aqueous solvent medium, in which the lipid bilayer membrane and the molecule are disposed, with a solute. The aqueous solvent medium, the lipid bilayer membrane and the molecule are then exposed to a sufficient partial pressure of the solute to cause the solute to dissolve in the aqueous solvent medium, whereby a significant portion of the solute migrates to the hydrophobic fatty acyl portion of the lipid bilayer membrane. The solute thereby allows a significantly increased migration of the molecule across the lipid bilayer membrane.

REFERENCES:
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Bouma et al., J. Biol. Chem., 252(19): 6759-6763.
Rand et al., Biochem., 29:76-87 (1990).
Ostro et al., Am. J. Hosp. Pharm., 46: 1576-1587 (1989).
Gruner, J. Phys. Chem., 1989(93):7562-7570 (1989).

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