Method and system for administering therapeutic and diagnostic a

Details Method and system for administering therapeutic and diagnostic a Method and system for administering therapeutic and diagnostic a

1986-06-23

1989-09-05

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 534 14, A61K 4902, A61K 4900, C07F 1300

Patent

active

048637130

ABSTRACT:
A method and system for localizing a diagnostic or therapeutic agent to an internal target site. The system includes (1) an epitopic compound, (2) a binding protein which is effective to bind specifically with the compound and capable of localizing selectively at the target tissue, when administered parenterally, and (3) a clearing agent which can bind to and cross-link the binding protein, to form a protein aggregate which is readily cleared from the subject's bloodstream. In practicing the method of the invention, the binding protein is administered to the subject parenterally, and allowed to localize at the target site, typically within 1-4 days. This is followed by a chase with the clearing agent to remove circulating, but not target-localized binding protein. When the epitopic compound is administered, binding of the compound to the localized binding protein, and rapid clearance of unbound compound by the kidneys, results in selective localization of the compound at the target site.

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The invention described herein was made in the course of work under contracts from the U.S. National Institutes of Health/NCI Grant Nos. 5 R01 CA28343, CA00462, and CA16861 of the Department of Health and Human Services.

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