Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1987-03-27
1990-02-27
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514179, 514180, 514913, A61K 3156
Patent
active
049046497
ABSTRACT:
A method for treating glaucoma consisting of exposing the eye to a corticosteroid and a beta adrenergic agent to the eye which acts to decrease ocular pressure. Useful adrenergic agents include beta agonists antagonists, including, for example, epinephrine, dipivalyl epinephrine, betaxolol, levobunolol, and timolol. Useful steroids, which are preferably applied topically, include dexamethasone, prednisolone, cortisone, and triamcinolone. The beta adrenergic agent is administered at a concentration between about 10% and 20% of the concentration that the agent is administered in its normal use. The corticosteroid is administered at a concentration between 5% and 10% of the concentration that the corticosteroid is administered in its normal use.
REFERENCES:
patent: 2801202 (1957-07-01), Poetsch
patent: 3320125 (1967-05-01), Grim
patent: 4255415 (1981-03-01), Chrai et al.
patent: 4271143 (1981-06-01), Schoenwald et al.
patent: 4474751 (1984-10-01), Haslam et al.
Martindale--The Extra Pharmacopoeia--28th Ed. (1982)--The Pharmaceutical Press--London, Eng., p. 447.
"Steroid Potentiation of Beta-Adrenengia-Sensitive Adenylate Cyclase in Rabbit Ciliary Processes" Harris et al. (1986).
Fay Zohreh A.
New England Medical Center Hospitals Inc.
Robinson Douglas W.
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