Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Reexamination Certificate
2006-09-26
2006-09-26
Chin, Christopher L. (Department: 1641)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
C422S068100, C422S082010, C435S006120, C435S007200, C435S287100, C435S287200, C436S524000, C436S527000, C436S149000, C436S150000, C436S151000, C436S806000, C310S311000, C310S312000, C310S31300R
Reexamination Certificate
active
07112452
ABSTRACT:
A method and sensor are provided for detecting the binding of a probe and a target biomolecule by measuring a difference in the shear stress on the surface of the sensor before and after hybridization of the target molecule to the probe, such as nucleic acids or proteins. The shear stress may be measured sensitively and conveniently as an electrical signal without additional fluorescent labeling and without use of expensive additional devices.
REFERENCES:
patent: 5372930 (1994-12-01), Colton et al.
patent: 6033913 (2000-03-01), Morozov et al.
patent: 6043031 (2000-03-01), Koster et al.
patent: 6090933 (2000-07-01), Kayyem et al.
patent: 6096273 (2000-08-01), Kayyem et al.
patent: 6141096 (2000-10-01), Stern et al.
patent: 0962759 (1999-12-01), None
patent: 0 962 759 (2003-08-01), None
patent: WO 01/23892 (2001-04-01), None
Adam B. Steel et al.; Electrochemical Quantitation of DNA Immobilized on Gold; Anal. Chem. 1998, 70, 4670-4677.
Daniel P. Little et al.; MALDI on a Chip: Analysis of Arrays of Low-Femtomole to Subfemtomole Quantities of Synthetic Oligonucleotides and DNA Diagnostic Products Dispensed by a Piezoelectric Pipet; Anal. Chem. 1997, 69, 4540-4546.
Yoshio Okahata et al.; Kinetic Measurements of DNA Hybridization of an Oligonucleotide-Immobilized 27-MHz Quartz Crystal Microbalance; Anal. Chem. 1998; 70: 1288-1296.
Mary E. Napier et al.; Probing Biomolecule Recognition with Electron Transfer: Electrochemical Sensors for DNA Hybridization; Bioconjugate Chem. 1997; 8; 906-913.
Koji Hashimoto et al.; Novel DNA sensor for electrochemical gene detection; Analytica Chimica Acta, 286 (1994) 219-224.
Guanghua Wu et al.; Origin of nanomechanical cantilever motion generated from biomolecular interactions; Proc. Natl. Acad. Sci.; Feb. 13, 2001; vol. 98; No. 4; pp. 1560-1564.
Steve Granick; Motions and Relaxations of Confined Liquids; Science; 1991; vol. 253; pp. 1374-1379.
Shana O. Kelley et al.; Photoinduced Electron Transfer in Ethidium-Modified DNA Duplexes: Dependence on Distance and Base Stacking; J. Am. Chem. Soc. 1997; 119, 9861-9870.
Claire E. Jordan et al.; Surface Plasmon Resonance Imaging Measurements of DNA Hybridization Adsorption and Streptavidin/DNA Multilayer Formation at Chemically Modified Gold Surfaces; Anal. Chem. 1997, 69, 4939-4947.
S. R. Sheth et al.; Interactions of Poly(ethylene oxide) Brushes with Chemically Selective Surfaces; J. Phys. Chem. B, 2000, 104, 7652-7662.
J. Fritz et al.; Translating Biomolecular Recognition into Nanomechanics; Science; Apr. 14, 2000; vol. 288; pp. 316-318.
“The surface force apparatus—a tool for probing molecular protein interactions”; NATURE. vol. 376; Aug. 17, 1995 Author: Deborah Leckband.
XP000219383; “Design of an Apparatus to Measure the Shear Response of Ultrathin Liquid Films”; 8127 Review of Scientific Instruments; 62(1991) Feb. No. 2, New York, US; Authors: James Peachey, John Van Alsten and Steve Granick; American Institute of Physics; pp. 463-473.
XP000525968; “The Surface Force Apparatus—A Tool for Probing Molecular Protein Interactions”; (PCT.195) 37 Natue; 376(1995) Aug. 17, No. 6541, London GB; Author: Deborah Leckband; pp. 671-618.
European Search Report of EP 02 02 3725, date of completion of the search Sep. 30, 2004.
Cho Yoon-kyoung
Kim Sun-hee
Lim Geun-bae
Oh Kwang-wook
Yoon Dae-sung
Cantor & Colburn LLP
Chin Christopher L.
LandOfFree
Method and sensor for detecting the binding of biomolecules... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and sensor for detecting the binding of biomolecules..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and sensor for detecting the binding of biomolecules... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3536405