Method and reagent for treatment of diseases caused by expressio

Details Method and reagent for treatment of diseases caused by expressio Method and reagent for treatment of diseases caused by expressio

1992-08-26

1998-05-12

Crouch, Deborah

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4353201, 435325, 435336, 536 232, 536 245, C12N 1510

Patent

active

057503907

ABSTRACT:
An enzymatic RNA molecule which cleaves bcl.2 mRNA associated with development or maintenance of follicular lymphoma.

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Seto et al., "Alternative promoters and exons, somatic . . . fusion gene in lymphoma", The EMBO Journal vol. 7, No. 1, 123-131, 1988.
Hua et al., "Mechanism of bcl-2 activation in human follicular lymphoma", Oncogene 1990, 5:233-235.
Hampel et al., "RNA Catalyst for Cleaving Specifiec RNA Sequences", filed Sep. 20, 1989, which is a Continuation-in-Part of U.S. Serial No. 07/247,100 filed Sep. 20, 1988.
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Mamone et al., "Design of Hammerhead Ribozymes Targeted to Sequences in HIV, HSV, and the Rat ANF Gene", Abstract of Keystone, CO (May 27, 1992).
Pavco et al., "Regulation of Self-Splicing Reactions by Antisense RNA", Abstract of Keystone, CO (May 27, 1992).
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Sarver et al (1990) Science 247, 1222-1225.
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