Method and reagent for sulfurization of organophosphorous compou

Details Method and reagent for sulfurization of organophosphorous compou Method and reagent for sulfurization of organophosphorous compou

1990-11-27

1993-10-12

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2534, 536124, 536126, C07H 100

Patent

active

052527239

ABSTRACT:
A composition suitable for sulfurizing an organophosphite. The reagent comprises a solution of sulfur and a non-aromatic tertiary amine, in a suitable solvent such as carbon disulfide. The non-aromatic tertiary amine is preferably an optionally substituted trialkyl amine, for example triethylamine or diisopropylethylamine. A method is also provided in which phosphites or phosphonates are sulfurized to their corresponding phosphorothioates or phosphonothioates, respectively, using compositions of the present invention. This method has particular application to produce internucleotide phosphorothioate or phosphonothioate bonds in a nucleotide multimer.

REFERENCES:
patent: 2536647 (1951-01-01), Kosolapoff
patent: 2647140 (1953-07-01), Jonas
patent: 2907787 (1959-10-01), Hoffman et al.
patent: 3162570 (1964-12-01), Wilson
patent: 3294874 (1966-12-01), Schrader
patent: 3296221 (1967-01-01), Stanley
patent: 3687808 (1972-08-01), Merigan et al.
patent: 4189453 (1980-02-01), Zinke et al.
patent: 4625677 (1986-12-01), Neher
Hata, T. & Sekine, M. Oxidation of Nucleoside Phosphites By Means of 2,2'Dipyridyl Disulfide Via Nucleoside Silylphosphite Intermediates Tetrahedron Letters No. 45, pp. 3943-3946 (1974).
Chen, J. & Benkovic, S. Synthesis and Separation of Diastereomers of Deoxynucleoside 5' O-(1-Thio) Triphosphiates.
Nucleic Acids Research 11, 3737-3751 (Jun. 11, 1983).
Lamande, L., et al.-Synthesis of a Triethylammonium Salt of a Spirophosphorane Containing a P-SH Bond.
Society of Chemical Communications 49, 2314-2317 (1984).

Affiliated with

Also associated with

Rating

Method and reagent for sulfurization of organophosphorous compou does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and reagent for sulfurization of organophosphorous compou, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and reagent for sulfurization of organophosphorous compou will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1905855