Method and reagent for quantitative analysis of 3-oxo-5.beta.-st

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving oxidoreductase

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435 25, C12Q 126, C12Q 132

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050859897

ABSTRACT:
A quantitative analysis of 3-oxo-5.beta.-steroid is carried out by acting 3-oxo-5.beta.-steroid.DELTA..sup.4 -dehydrogenase on a sample in the presence of a reducing chromophoric agent, and measuring the optical density of the chromophoric substance thereby produced. A typical reducing chromophoric agent is a tetrazolium compound. The invention also provides a reagent for the quantitative analysis of 3-oxo-5.beta.-steroid comprising 3-oxo-5.beta.-steroid.DELTA..sup.4 -dehydrogenase and a tetrazolium compound. The analysis and reagent provide a simple and reliable method for a liver function test.

REFERENCES:
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Christiansen et al., Chemical Abstracts, 103:84307m, 9/16/85, p. 303.
Chemical Abstracts, vol. 107, No. 13, Sept. 28, 1987, p. 306 abstract No. 111955n.
Chemical Abstract, vol. 76, No. 13, Mar. 27, 1972, p. 138 abstract No. 69430b.
Comprehensive Biochemistry, vol. 13, 3rd Ed., pp. 80,81 Florkin et al.

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