Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1997-08-20
1999-11-02
Leary, Louise N.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 24, 435 4, 435968, 435 29, 435 34, C12Q 137, C12Q 100
Patent
active
059768223
ABSTRACT:
The ability to determine the stage or pathway of cysteine proteases in a single cell assay has long been desired as a material event in apoptosis. The present invention relates to a method and assay reagents for determining enzyme activity and relating said activity to the apoptotic pathway. In addition, the method find utility in distinguishing apoptotic activity from necrotic activity.
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Alnemri, E., et al., "Human ICE/CED-3 Protease Nomenclature," Cell, vol. 87, p. 171, 1996.
Enari, M., et al., "Sequential Activation of ICE-like and CPP32-like Proteases during FAS-Mediated Apoptosis," Nature, vol. 380, pp. 723-726, Apr. 25, 1996.
Gross, E., eds. The Peptides: Analysis, Synthesis, Biology, vol. 3, pp. 3-99, Academic Press, 1981.
Duque, R.E., "Flow Cytometric Analysis of Lymphomas and Acute Leukemias," Ann. NYAS, Clinical Flow Cytometry, 677, pp. 309-325, Mar. 20, 1993.
Del Valle Ursino
Galiounghi Adry
Garcia Nancy
Landrum Eileen
Lucas Frank J.
Alter Mitchell E.
Coulter International Corp.
Leary Louise N.
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