Method and reagent for making a radiopharmaceutical composition

Details Method and reagent for making a radiopharmaceutical composition Method and reagent for making a radiopharmaceutical composition

1981-07-27

1984-01-24

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, A61K 4300, A61K 4900

Patent

active

044276478

ABSTRACT:
A method of making a radiopharmaceutical composition by mixing an aqueous solution of pertechnetate with a reducing agent comprising tin metal or stannous ion to reduce the pertechnetate and a complexing agent to form a complex with the reduced technetium, is characterized by incorporating nitrate and/or nitrite in an amount to diminish oxidation of Sn.sup.2+ to Sn.sup.4+, and hence to prevent re-oxidation of technetium to pertechnetate, during preparation and storage of the complex. Nitrate and nitrite are superior to organic antioxidants previously proposed.
A reagent for the purpose comprises the reducing agent, the complexing agent and the nitrate and/or nitrite usually in a sterile freeze-dried state.

REFERENCES:
patent: 3962412 (1976-06-01), Wolfangel
patent: 4075314 (1978-02-01), Wolfangel et al.
Dumortier et al., Int. J. Appl. Rad. Isotopes, 25 (1974) 189-191.

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