Method and reagent for inhibiting hepatitis C virus replication

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 9131, 4351723, 4353201, 435325, 435366, 536 231, 536 232, 536 245, C12Q 168, C07H 2104

Patent

active

058692533

ABSTRACT:
An enzymatic RNA molecule which specifically cleaves RNA of a hepatitis C virus.

REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5298612 (1994-03-01), Jennings et al.
Dropulic et al., "Functional Characterization of a U5 Ribozyme: Intracellular Suppression of Human Immunodeficiencty Virus Type I Expression," Journal of Virology 66:1432-1441 (1992).
He et al., "In Vitro cleavage of HPV16 E6 and E7 mRNA by designed ribozymes," Chemical Abstracts vol, 120, No. 1 at abstract No. 3342 (1994).
He et al., "In Vitro cleavage of HPV16 E6 and E7 mRNA by designed ribozymes," FEBS Letters 322:21-24 (1993).
Lu et al., "Ribozyme-mediated in vitro cleavage of transcripts arising from the major transforming genes of human papillomavirus type 16," Cancer Gene Therapy 1(4):267-277 (1994).
Rossi and Sarver, "RNA enzymes (ribozymes) as antiviral therapeutic agents," TIBTECH 8:179-183 (1990).
Rossi et al., "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems," Aids Research and Human Retroviruses 8:183-189 (1992).
Rossi et al., "Ribozymes as potential therapeutic agents," Proc. Annu. Meeting Am. Assoc. Cancer Res. 34:592-593 (1993).
Rossi et al., "Ribozymes As Therapies For AIDS," Annals of the New York Academy of Sciences 606:184-200 (1990).
von Weizsacker et al., "Cleavage of Hepatitis B Virus RNA by Three Ribozxymes Transcribed From a Single DNA Template," Biochemical and Biophysical Research Communications 189:743-748 (1992).
Wong-Staal, "Molecular targets for interference with viral replication," International Conference on AIDS 9(1):10 (1993).
Baringa, "Ribozymes: Killing the Messenger," Science 262:1521-1514 (1993).
Cech, "Ribozymes and Their Medical Implications," JAMA 260:3030-3034 (1988).
Choo, et al., "Genetic organization and diversity of the hepatitis C virus," Proc. Natl. Adac. Sci. USA 88:2451 (1991).
Christoffersen et al., "Application of computational technologies to ribozyme botechnology products," Journal of Molecular Structure (Theochem) 311:273-284 (1994).
Guerrier-Takada et al., "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme," Cell 35:849-857 (1983).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)sTRSV Sequence," Biochemistry 28:4929-4933 (1989).
Hampel et al., "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirememt for Substrate RNA," Nucleic Acids Research 18:299-304 (1990).
Haseloff and Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities," Nature 334:585-591 (1988).
Jeffries and Symons, "A Catalytic 13-mer Ribozyme," Nucleic Acids Research 17:1371-1377 (1989).
Johnston and Hoth, "Present Status and Future Prospects for HIV Therapies," Science 260:1286-1293 (1993).
Kashani-Sabet et al., "Reversal of the Malignant Phenotype by an Anti-ras Ribozyme," Antisense Research & Development 2:3-15 (1992).
Kim and Cech, "Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena," Proc. Natl. Acad. Sci. USA 84:8788 (1987).
Mamone et al., "Design of Hammerhead Ribozymes Targeted to Sequences in HIV, HSV and the RAT ANF Gene," Abstract of Keystone, CO (May 27, 1992).
Martell et al., J. Hepatol. Suppl. 2 13:551 (1991).
Okamoto et al., Virology 190:894 (1990).
Pavco et al., "Regulation of Self-Splicing Reactions by Antisense RNA," Abstract of Keystone, CO (May 27, 1992).
Perrotta and Been, "Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .delta.Virus RNA Sequence," Biochemistry 31:61-21 (1992).
"RNAzyme Tet 1.0 Kit," U.S. Biochemicals Editorial Comments 16(2):8-9 (1989).
"Ribozymes," U.S. Biochemicals Editorial Comments 16(2):1-5 (1989).
Rossi et al, "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems," Aids Research and Human Retroviruses 8:1983-189 (1992).
Rossi et al., "Ribozyme Mediated Intracellular Immunity to HIV-1 in CD4," J. Cell Biochem. Suppl 14A:D428 (1990).
Sarver et al., "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents" Science 247:1222-1225 (1990).
Stull and Szoka, "Antigene, Ribozyme and Aptamer Nucleic Acid Drugs: Progress and Prospects," Pharmaceutical Research 12:465-483 (1995).
Tanaka et al., "Molecular cloning of hepatitis C virus genome from a single Japanese carrier: sequence variation within the same individual and among infected individuals," Virus Research 23:39 (1992).
Tsukiyama-Kohara et al., "Internal Ribosome Entry Site Within Hepatits C Virus RNA," Journal of Virology 66:1476-1483 (1992).
Weerasinghe et al., "Resistance to Human Immunodeficiency Virus Type 1 (HIV-1) Infection in Human CD4.sup.+ Lymphocyte-Derived Cell Lines Conferred by Using Retroviral Vectors Expressing an HIV-1 RNA-Specific Ribozyme," Journal of Virology 65:5531-5534 (1994).
Yoo et al., Virology 191:889 (1992).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method and reagent for inhibiting hepatitis C virus replication does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and reagent for inhibiting hepatitis C virus replication, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and reagent for inhibiting hepatitis C virus replication will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1947598

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.