Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1978-09-19
1981-04-28
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 15, 424 15, C12Q 168, C12Q 148
Patent
active
042647290
ABSTRACT:
The effects of a substance on the replication process in vitro of ADN separated from sound tissues (check tissue) on the one hand and of DNA separated from cancerous tissue (cancerous DNA) on the other hand, are being compared. Cancerigenic substances are identified since they stimulate the replication of cancerous DNA more strongly than the replication of check tissue; specifically anticancerous substances since they inhibit the replication of cancerous DNA but not the replication of check tissue, toxic substances since they inhibit the replication of cancerous DNA as well as that of check tissue; and neutral substances since they do not have any effect either on the replication of cancerous DNA or on that of check tissue.
REFERENCES:
patent: 3755086 (1973-08-01), Heimer
patent: 3798131 (1974-03-01), Rounds et al.
patent: 4066510 (1978-01-01), Thilly
patent: 4072574 (1978-02-01), Loeb et al.
Shirasaka, et al., "Purification of Thymidine Kinase Yoshida Sarcoma by Affinity Chromatography, and DNA Synthesis in Tumor-Bearing Rats.", Chem. Abstracts, vol. 83, No. 5, p. 343, (1975), Abs. No. 41213d.
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