Method and quantification assay for determining...

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Reexamination Certificate

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C435S007100, C436S544000

Reexamination Certificate

active

07419777

ABSTRACT:
This invention provides methods for determining or predicting response to cancer therapy in an individual using differential image analysis of immunohistochemically stained tumor samples.

REFERENCES:
patent: 5288477 (1994-02-01), Bacus
patent: 5536642 (1996-07-01), Barbera-Guillem et al.
patent: 2001/0044124 (2001-11-01), Bacus
patent: 2001/0049114 (2001-12-01), Bacus
patent: 2000-515964 (2000-11-01), None
patent: WO 96/17873 (1996-06-01), None
patent: WO 99/41613 (1999-08-01), None
patent: WO 99/53953 (1999-10-01), None
patent: WO 01/25473 (2001-04-01), None
patent: WO 01/51924 (2001-07-01), None
patent: WO 01/51928 (2001-07-01), None
Heinrich et al (Blood, Aug. 2000, vol. 96, pp. 925-932).
Landuzzi et al (American Journal of Pathology, Dec. 2000, vol. 157, pp. 2123-2131).
Schlom (‘Monoclonal Antibodies: They're More and Less Than You Think’, In: Molecular Foundations of Oncology, S. Broader, Ed, 1991, pp. 95-134).
Arteaga et al., “p185c-erbβ-2Signaling Enhances Cisplatin-induced Cytotoxicity in Human Breast Carcinoma Cells: Association between an Oncogenic Receptor Tyrosine Kinase and Drug-Induced DNA Repair,” Cancer Res., 54:3758-3765, 1994.
Bacus et al., “Potential Use of Image Analysis for the Evaluation of Cellular Predicting Factors for Therapeutic Response in Breast Cancers,” Anal. Quant. Cytol. Histol., 19:316-328, 1997.
Cantley and Neel, “New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositude 3-kinase/AKT pathway,” Proc. Natl. Acad. Sci. U.S.A., 96:4240-45, 1999.
Chui et al., “Immunohistochemical expression of the c-kit proto-oncogene product in human malignant and non-malignant breast tissues,” British J. of Cancer, 73:1233-1236, 1996.
Cobleigh et al., “Mutinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease,” J. Clin. Oncol., 17:2639-2648, 1999.
Datta et al., “Cellular survival: a play in three Akts,” Genes and Dev., 13:2905-27, 1999.
DiGiovanna, “Clinical Significance of HER-2
eu Overexpression: Part I,” PPO Updates: Princ. Practice Oncol., 13:1-9, 1999.
Hancock et al., “A Monoclonal Antidoby against the c-erbβ-2 Protein Enhances the Cytotoxicity ofcis-Diamminedichloroplatinum against Human Breast and Ovarian Tumor Cell Lines,” Cancer Res., 51:4575-4580, 1991.
Hines et al., “Coexpression of c-kit and stem cell factor in breast cancer results in enhanced sensitivity to members of the EGF family of growth factors,” Breast Cancer Research and Treatment 58: 1-10, 1999.
Hines, et al., “Coexpression of the c-kit and Stem Cell Factor Genes in Breast Carcinomas,” Cell Growth & Differentiation, 6:769-779, 1995.
Hortobagyi, “High-Dose Chemotherapy for Primary Breast Cancer: Facts Versus Anecdotes,” J. Clin. Oncol., 17:25-29, 1999.
Kuerbitz et al., “Wild-type p53 is a cell cycle checkpoint determinant following irradiation,” Proc. Natl. Acad. Sci. USA, 89:7491-95, 1992.
Kwok and Sutherland, “Epidermal Growth Factor Reduces Resistance to Doxorubicin,” Int. J. Cancer, 49:73-76, 1991.
Kwok and Sutherland, “Enhancement of Sensitivity of Human Squamous Carcinoma Cells to Radiation by Epidermal Growth Factor,” J. Natl. Cancer Inst., 81:1020-24, 1989.
Lane, “p53, guardian of the genome,” Nature, 358:15-16, 1992.
Li et al., “PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer,” Science 275:1943-47, 1997.
Liaw et al., “Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome,” Nat. Genet., 16:64-67, 1997.
Liu et al., “Regulation of p21WAF1/CIP1Expression through Mitogen-activated Protein Kinase Signaling Pathway,” Cancer Res., 56:31-35, 1996.
Luo et al., “Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1,”Nature, 375:159-61, 1995.
Mendelsohn, “The epidermal growth factor receptor as a target for therapy with antireceptor monoclonal antibodies,” Semin. Cancer Biol., 1:339-44, 1990.
Natali et al., “Breast cancer is associated with loss of the c-kit oncogene product,” Int. J. Cancer, 52:713-717, 1992.
Nelen et al., “Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease,” Hum. Mol. Genet., 6:1383-87, 1997.
Pietras et al., “Antibody to HER-2
eu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells,” Oncogene, 9:1829-38, 1994.
Shak, “Overview of the Trastuzumab (Herceptin) Anti-HER2 Monoclonal Antibody Clinical Program in HER2-Overexpressing Metastatic Breast Cancer,” Semin. Oncol., 26:71-77, 1999.
Sliwkowski et al., “Nonclinical Studies Addressing the Mechanism of Action of Trastuzumab (Herceptin),” Semin. Oncol., 26:60-70, 1999.
Vincent et al., “Anticancer efficacy of the irreversible EGFr tyrosine kinase inhibitor PD 0169414 against human tumor xenografts,” Cancer Chemother. Pharmacol., 45:231-38, 2000.
Yarden et al., “Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand,” EMBO J. 6:3341-3351, 1987.
Winter-Vann Am et al., “Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate,” Proc. Natl. Acad. Sci. USA 100(11):6529-6534, May 27, 2003.
West et al., “Activation of the PI3K/Akt pathway and chemotherapeutic resistance,” Drug Resist Updat. 5(6):234-248, Dec. 2002.
Rusnak et al., “The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo,” Mol. Cancer Ther. 1:85-94, Dec. 2001.
DeMatteo, “The GIST of targeted cancer therapy: a tumor (gastrointestinal stromal tumor), a mutated gene (c-kit), and a molecular inhibitor (STI571),” Ann. Surg. Oncol. 9(9):831-839, Nov. 2002.
Stal et al., “Akt kinases in breast cancer and the results of adjuvant therapy,” Breast Cancer Res. 5:R37-R44, 2003.
Glaspy, “Clinical applications of stem cell factor,” Curr. Opin. Hematol. 3(3):223-229, May 1996.
Krystal et al., “The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth,” Clin. Cancer Res. 6:3319-3326, Aug. 2000.
Hassan et al., “Stem cell factor as a survival and growth factor in human normal and malignant hematopoiesis,” Acta Haematol. 95(3-4):257-262, 1996.
Radosevic et al., “Cell cycle regulatory protein expression in fresh acute myeloid leukemia cells and after drug exposure,” Leukemia 15(4):559-566, Apr. 2001.
Nio et al., “Immunohistochemical expression of receptor-tyrosine kinase c-kit protein in invasive ductal carcinoma of the pancreas,” Anticancer Drugs 14(4):313-319, Apr. 2003.
Pertussini et al., “investigating the platelet-sparing mechanism of paclitaxel/carboplatin combination therapy,” Blood 97(3)638-644, Feb. 1, 2001.
Kausch et al., “Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscule cells,” Biochem Biophys. Res. Cummun. 280(3):664-674, Jan. 26, 2001.
Ciocca et al., “Molecular markers for predicting response to tamoxifen in breast cancer,” Endocrine 13(1):1-10, Aug. 2000.
Bacus et al., “AKT2 is frequently upregulated in HER-2
eu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival,” Oncogene 21(22):3532-3540, May 16, 2002.
Beck et al., “Expression of stem cell factor and its receptor by human neuroblastoma cells and tumors,” Blood 86(8)

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