Method and products for detection of human T cell leukemia virus

Details Method and products for detection of human T cell leukemia virus Method and products for detection of human T cell leukemia virus

1984-04-13

1988-05-10

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530395, 424 89, 435 5, 435 68, 435235, 435518, 435 7, 435188, 436531, 436533, 436542, 436543, 436544, 436545, 436546, 436 8B, 436823, C07K 1504

Patent

active

047436786

ABSTRACT:
A first glycoprotein having a molecular weight of approximately 61,000-68,000 daltons in the MJ, C5-MJ, C91 PL or HUT-102 cell lines, of which 46,000 to 48,000 is the unglycosylated moiety, is obtained from cells infected with human T cell leukemia virus. A second glycoprotein having a molecular weight of approximately 45,000-52,000 daltons is also obtained from such cells and is in large part identical to the NH.sub.2 -terminal end of the first glycoprotein. The presence, in a biological specimen, of antibody to the antigenic determinant of either of these proteins is indicative of the presence of cells infected by human T cell leukemia virus. An assay for the antibody is a useful diagnostic procedure for determining such infection in biologial specimens.

REFERENCES:
patent: 4126671 (1978-11-01), House et al.
patent: 4282315 (1981-04-01), Luderer et al.
patent: 4379839 (1983-04-01), Spiegelman
patent: 4406885 (1983-09-01), Pinter
patent: 4434157 (1984-02-01), Olsen
patent: 4525300 (1985-06-01), Yoshida et al.
Wong-Staal, F. and Gallo, R. C., Nature 317:395-403 (Oct. 1985), review article.
Sodroski, J. et al., Science 225:421-424 (Jul. 1984).
Schupbach, J. et al., Science 224:607-609 (May 1984).
Rice, N. R. et al., Virology 138:82-93 (1984).
Devare, S. G. et al., Journal of Virology, 23(2):443-447 (1977).
Kobayashi, N. et al., the EMBO Journal, 3(2):321-325 (1984).
Seiki, M. et al., Proc. Natl. Acad. Sci., U.S.A., 80:3618-3622 (6-1983).
Kalyanaram, V. S. et al., Journal of Virology, 38(2):906-915 (6-1981).
Hopp, T. P. et al., Proc. Natl. Acad. Sci., U.S.A. 78(6):3824-3828 (6-1981).
Prince, A. M. et al., Proc. Natl. Acad. Sci., U.S.A. 79(2):579-582 (1-1982).
Fine, D. L. et al., Virology 101,176-184 (1980).
Cianciolo, G. et al., Journal of Leukocyte Biology 36(2): 213-214 (1984).
Azocar et al., Journal of the National Cancer Institute, vol. 63, 1179-1184 (1979).
Hinuma et al., Proc. Natl. Acad. Sciences, U.S.A., vol. 78, 6476-6480 (1981).
Posner et al., J. Exp. Med., vol. 154, 333-346 (1981).
Robert-Guroff et al., Science, vol. 215, 975-978 (1982).
Potocnjak et al., Science, vol. 215, 1637-1639 (1982).
Yoshida et al., PNAS, vol. 79, 2031-2035 (1982).
Essex, J. Nat'l Cancer Institute, vol. 69, 981-5 (1982).
Yamamoto et al., Int. J. Cancer, vol. 30, 289-293 (1982).
Yamamoto et al., Z. Naturforsch., vol. 37c, 731-732 (1982).
Fields et al., Nature, vol. 300, 19-23 (1982).
Hinuma, GANN Monograph on Cancer Research, vol. 28, 211-218 (1982), Plenum Pres, N.Y., Hanaoka, M. et al. eds.
Miyoshi et al., GANN Monograph on Cancer Research, vol. 28, 219-237 (1982).
Popovic et al., Science, vol. 219, 856-859 (1983).
Miyoshi et al., GANN, vol. 74, 1-4 (Feb. 1983).
Taguchi et al., GANN, vol. 74, 185-187 (Apr. 1983).
Yamamoto et al., Int. J. Cancer, vol. 32, 281-287 (1983).
Essex et al., Science, vol. 220, 859-862 (May 1983).
Miyoshi et al., GANN, vol. 74, 323-326 (Jun. 1983).
Tanaka et al., GANN, vol. 74, 327-330 (Jun. 1983).
Essex et al., Science, vol. 221, 1061-1064 (Sep. 1983).
Hattori et al., GANN, vol. 74, 790-793 (Dec. 1983).
Poiesz et al., PNAS (U.S.A.), vol. 77, 7415-7419 (1980).
Watanabe et al., Science, vol. 222, p. 1178ff, Dec. 16, 1983.
Sacks et al., J. Exp. Med., vol. 155, 1108-1119 (1982).
Leukemia Reviews International, vol. 1, Jul. 3, 1983.
Schneider et al., Detection and Isolation of Envelope and Core Polypeptides from ATLV, pp. 46-47.
Lee et al., Cell Surface Antigens Associated with Human Adult T-Cell Leukemia-Lymphoma, p. 93ff.
McLane et al., Distribution of Antibodies to HTLV-Associated Cell Membrane Antigen, p. 103ff.
Howe et al., Cytotoxic Antibodies in Patients with Adult T-Cell Leukemia-Lymphoma, pp. 184-185.
RNA Tumor Viruses, Cold Spring Harbor Lab., May 25-29, 1983.
Lee et al., HTLV Associated Memb
This invention was made in the course of work supported by the United States Government, which has certain rights in the invention.

Affiliated with

Also associated with

Rating

Method and products for detection of human T cell leukemia virus does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and products for detection of human T cell leukemia virus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and products for detection of human T cell leukemia virus will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1321819