Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1984-04-13
1988-05-10
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530395, 424 89, 435 5, 435 68, 435235, 435518, 435 7, 435188, 436531, 436533, 436542, 436543, 436544, 436545, 436546, 436 8B, 436823, C07K 1504
Patent
active
047436786
ABSTRACT:
A first glycoprotein having a molecular weight of approximately 61,000-68,000 daltons in the MJ, C5-MJ, C91 PL or HUT-102 cell lines, of which 46,000 to 48,000 is the unglycosylated moiety, is obtained from cells infected with human T cell leukemia virus. A second glycoprotein having a molecular weight of approximately 45,000-52,000 daltons is also obtained from such cells and is in large part identical to the NH.sub.2 -terminal end of the first glycoprotein. The presence, in a biological specimen, of antibody to the antigenic determinant of either of these proteins is indicative of the presence of cells infected by human T cell leukemia virus. An assay for the antibody is a useful diagnostic procedure for determining such infection in biologial specimens.
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This invention was made in the course of work supported by the United States Government, which has certain rights in the invention.
Essex Myron E.
Lee Tun-Hou
Moskowitz Margaret
President and Fellows of Harvard College
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