Method and products for detection of human T cell leukemia virus

Details Method and products for detection of human T cell leukemia virus Method and products for detection of human T cell leukemia virus

1987-12-10

1991-09-03

Nucker, Christine

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 792, 435975, 4352351, 530350, 530395, G01N 33569, G01N 33535

Patent

active

050454480

ABSTRACT:
A first glycoprotein having a molecular weight of approximately 61,000-68,000 daltons in the MJ, C5-MJ, C91 PL or HUT-102 cell lines, of which 46,000 to 48,000 is the unglycosylated moiety, is obtained from cells infected with human T cell leukemia virus. A second glycoprotein having a molecular weight of approximately 45,000-52,000 daltons is also obtained from such cells and is in large part identical to the NH.sub.2 -terminal end of the first glycoprotein. The presence, in a biological specimen, of antibody to the antigenic determinant of either of these proteins is indicative of the presence of cells infected by human T cell leukemia virus. An assay for the antibody is a useful diagnostic procedure for determining such infection in biological specimens.

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This invention was made in the course of work supported by the United States Government, which has certain rights in the invention.

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