Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-05-05
2009-08-18
Cook, Lisa V (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007500, C435S007910, C435S007920, C435S069700, C436S501000
Reexamination Certificate
active
07575874
ABSTRACT:
This invention relates to the detection of fusion proteins. The invention provides a set of at least a first and a second molecular probe, each probe provided with a dye wherein the dyes together allow energy transfer, at least one probe provided with a reactive group allowing juxtaposing at least the first and second probes wherein the reactive group allows to modulate of juxtaposing the probes such that there is an increased likelihood of energy transfer between the dyes. A method is provided which permits detecting the presence of a fusion protein in a cell at the single cell level.
REFERENCES:
patent: 1 382 965 (2004-01-01), None
patent: WO 01/75453 (2001-10-01), None
patent: WO 02/088733 (2002-11-01), None
patent: WO 2004/042398 (2004-05-01), None
Kane et al. (Analytical Biochemistry, vol. 278, 2000, pp. 29-38).
Emig et al., Accurate and rapid analysis of residual disease in patients with CML using specific fluorescent hybridization probes for real time quantitative RT-PCR, Leukemia, 1999, pp. 1825-1832, vol. 13, No. 11.
Ueda et al., Homogeneous Noncompetitive Immunoassay Based on the Energy Transfer Between Fluorolabeled Antibody Variable Domains (Open Sandwich Fluoroimmunoassay), BioTechniques, Oct. 1999, pp. 738-742, vol. 27.
PCT International Preliminary Examination Report, PCT/NL03/00776, dated Feb. 10, 2005.
PCT Search Report, PCT/NL03/00776, dated Mar. 12, 2004.
Cook Lisa V
Erasmus Universiteit Rotterdam
TraskBritt P.C.
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