Method and probe for identifying bacterial virulence...

Details Method and probe for identifying bacterial virulence... Method and probe for identifying bacterial virulence...

2008-04-01

2008-04-01

Gitomer, Ralph (Department: 1657)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

10526461

ABSTRACT:
A method for identifying antibacterial agents comprises depleting bacteria of a strain comprising a luxAB construct of Ca2+, incubating the Ca2+depleted bacteria with an agent the antibacterial effect of which shall be determined, recording the light emitted by the bacteria upon addition of an aldehyde, the incubation being carried out at a temperature which is at least 10° C. higher than the temperature at which the light is emitted by the bacteria. Also disclosed are corresponding probes and antibacterial agents identified by the method.

REFERENCES:
patent: 6136541 (2000-10-01), Demers et al.
patent: 2365426 (2002-02-01), None
patent: WO 98/07745 (1998-02-01), None
patent: WO99/11262 (1999-03-01), None
patent: WO-02/43668 (2002-06-01), None
Ciampa et al. STN search abstract.
Leemann et al. STN search abstract.
Ainscough et al. Journal of Inorganic Biochemistry 1999;77:125-133.
Kidwai et al., Indian Journal of Chemistry, vol. 39B, pp. 458-461 (2000).
Srivastava et al., Pharmazie, vol. 45, , pp. 34-37 (1990).
Covello et al., “New iodine containing organic compounds. Nuovi iodorganici di sintesi; Idrossibenzanilidi iodurate, Iodinated hydroxybenzanilides”; Rendiconto dell'Accademia delle Scienze Fisiche e Matematiche, vol. 33, pp. 309-318 (Naples) (1966).
Ainscough et al., Journal of Inorganic Biochemistry , vol. 77, pp. 125-133 (1999).
National Library of Medicine (NLM), file Medline, PMID: 8173809, Forsberg, A: “In vivo expression of virulence genes ofYersinia pseudotuberculosis”; Infect Agents Dis Aug. 1993; 2(4); 275-8.
ASM Abstract Database 2002 General Meeting (May 19, 2002 through May 23, 2002) American Society for Microbiology, Vladimir Motin, et al.: “Genome-Wide Expressing Profiling ofYersinia pestisDuring Low-Calcium Response”; retrieved Apr. 4, 2003 from http://www.asmusa.org/memonly/abstracts/AbstractView.asp?AbstractID=62023.
Infection and Immunity, vol. 43(1); Jan. 1984; Ingrid Bolin, et al.; “Molecular Cloning of the Temperature-Inducible Outer Membrane Protein 1 ofYersinia pseudotuberculosis”; p. 72-78.
Molecular Microbiology, vol. 2(2); 1988; Ingrid Bolin, et al.; “The plasmid-encoded Yop2b protein ofYersinia pseudotuberculosisis a virulence determinant regulated by calcium and temperature at the level of transcription”; p. 237-245.
STN International, File Caplus, Caplus accession No. 1968:95469, Document No. 68:95469, Giuseppe Ciampa, et al.; “N-Substituted salicylamides. I. Halogenated 2-hydroxy-and 2-acetoxybenzanilides with antibacterial and antifungal activity”; Rendiconto dell'Academia delle Scienze Fisiche e Matematiche, Naples 1966, 33(Dec.), 386-95.
STN International, File Caplus, Caplus accession No. 1978:94851, Document No. 88:94851, “Anthelminticcompositions based on benzimidazoles”; FR, A, 2336931, 19770729.
STN International, File Caplus, Caplus accession No. 1979:16910, Document No.: 90:16910, E.M. Shilakadze, et al.; “Antituberculosis activity of beta- and gamma-pyridinecarboxylic acid phenylhydrazones and their manganese(II) and manganese(III) complexes”; Soobshcheniya Akademii Nauk Gruzinskoi SSR (1978), 91(1), 145-8, esp. compound RN=68639-26-9.
STN International, File Caplus, Caplus accession No. 1992:645585, Document No. 117:245585, Ivanovo Agricultural Institute: “Method for treatment of fascioliasis and monieziaosis in sheep”; SU, A1, 1715357, 19920228.
STN International, File Caplus, Caplus accession No. 1977:189559, Document No. 86:189559, Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt., Hung.: “Salicylanilides”; BE, A1, 839873, 19760716.
STN International, File Caplus, Caplus accession No. 1985:487603, Document No.: 103:87603, J. M. Patel, et al.; “Studies on antitubercular and antibacterial agents: preparation of 1-(4-aminobenzoyl)-2-benzalhydrazine and 1-(4-(phenylthioureido)benzoyl)-2-substituted-benzalhydrazine”; Journal of the Indian Chemical Society; 1984; 61(8); 718-20.
STN International, File Caplus, Caplus accession No. 2002:298309, Document No. 137:169451, Vipin Kumar, et al.; “Synthesis and biological activities of 2-aryl-3-substituted benzamido-1,3-thiazolidin-4-ones” Indian Journal of Heterocyclic Chemistry; 2002; 11(13); 251-252.
J. Med. Chem.; vol. 41, 1998, Mark J. Macielag, et al.; “Substituted Salicylanilides as Inhibitors of Two-Component Regulatory Systems in Bacteria”; p. 2939-2945.
STN International, File Caplus, Caplus accession No. 2000:780229, Document No. 134:71527; Mazaahir, Kidwai, et al.; “Microwave assisted synthesis of new fungicidal pyrazoles”; Indian Journal of Chemistry; 2000; 39B(6); 458-461.
STN International, File Caplus, Caplus accession No. 2002:11847, Document No. 136:272653; K. Waisser, et al.; “2H-1,3-benzoxazine-2,4(3H)-diones substituted in position 6 as antimycobacterial agents”; Chemical Papers; 2001; 55(5); 323-334.
STN International, File Caplus, Caplus accession No. 1990:440580, Document No. 113:40580; R. P. Srivastava, et al.; “Synthesis of 2,5-disubstituted benzimidazoles, 1,3,4-thiadiazoles and 3,5-diiodosalicylanilides as structural congeners of rafoxanide and closantel”; Pharmazie (1990), 45(1), 34-7.
STN International, File Caplus, Caplus accession No. 1968:458923, Document No. 69:58923, Mario Covello, et al.; “New iodine containing organic compounds. Iodinated hydroxybenzanilides”; Rendiconto dell'Accademia delle Scienze Fisiche e Matematiche, Naples (1966), 33(Dec.), 309-18.
STN International, File Caplus, Caplus accession No. 2000:72793, Document No. 132:202643, Eric W. Ainscough, et al.; “Cytotoxicity of salicylaldehyde benzoylhydrazone analogs and their transition metal complexes: quantitative structure-activity relationships”; Journal of Inorganic Biochemistry (1999), 77(3-4), 125-133.
STN International, File Caplus, Caplus accession No. 1999:184132, Document No. 130:204267, Michael Brandt, et al.; “MPL-receptor ligands, process for their preparation, medicaments containing them, and their use for the treatment and prevention of thrombocytopenia and anemia”; PCT Int. Appl., 42 pp.
Database Registry; CAS RN:s 400054-03-7, 305338-58-3, 303084-13-1, 416883-56-2, and 341979-94-0.
STN International, File Caplus, Caplus accession No. 1998:147346, Document No. 128:213381, Janet R. Fraser, et al.; “Compositions and methods for treating infections using analogs of indolicidin”; PCT Int. Appl., 130 pp.
STN International, File Caplus, Caplus accession No. 1971:74914, Document No. 74:74914; A. P. Bekhli, et al.; “Synthesis of phenasal esters and their anthelmintic activity”; Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1970), 39(5), 532-4.

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