Method and preparing fused oxazinones

Details Method and preparing fused oxazinones Method and preparing fused oxazinones

2007-10-02

2007-10-02

Habte, Kahsay (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C544S094000

Reexamination Certificate

active

10554090

ABSTRACT:
A method for preparing a fused oxazinone is disclosed in which a carboxylic acid is contacted with a sulfonyl chloride and an isatoic anhydride in the presence of a tertiary amine, the nominal mole ratio of said sulfonyl chloride to said carboxylic acid being from about 1.0 to 1.5 and the nominal mole ratio of said isatoic anhydride to said carboxylic acid is from about 0.8 to 1.2. Also disclosed is a method for preparing a compound of Formula (III), using a compound of Formula (1a) that is characterized by preparing the fused oxazinone of Formula (1a) by the method above, using a compound of the formula LS(O)2Cl as the sulfonyl chloride, a compound of Formula (2′) as the carboxylic acid, and a compound of Formula (5′) as the isatoic anhydride wherein L, X, Y and R1through R9are as defined in the disclosure

REFERENCES:
patent: 6747047 (2004-06-01), Lahm et al.
patent: 6965032 (2005-11-01), Freudenberger et al.
patent: 2004/0102324 (2004-05-01), Annis et al.
patent: 2004/0110777 (2004-06-01), Annis et al.
patent: 2004/0138450 (2004-07-01), Clark
patent: 2004/0142984 (2004-07-01), Lahm et al.
patent: 2004/0171649 (2004-09-01), Annis et al.
patent: 2004/0186141 (2004-09-01), Zimmerman
patent: 2004/0192731 (2004-09-01), Finkelstein et al.
patent: 2004/0198984 (2004-10-01), Lahm et al.
patent: 2004/0209923 (2004-10-01), Berger et al.
patent: 2004/0259913 (2004-12-01), Clark
patent: 2005/0075372 (2005-04-01), Lahm et al.
patent: 2005/0124600 (2005-06-01), Clark et al.
patent: 2005/0147633 (2005-07-01), Stevenson
patent: 2005/0215785 (2005-09-01), Taylor
patent: 2005/0215798 (2005-09-01), Annis
patent: 2005/0245580 (2005-11-01), Fruedenberger et al.
patent: 2005/0282868 (2005-12-01), Finkelstein et al.
patent: WO 03/015519 (2003-02-01), None
patent: WO 03/106427 (2003-12-01), None
patent: WO 2004/033468 (2004-04-01), None
patent: WO 2004/046129 (2004-06-01), None
patent: WO 2004/067528 (2004-09-01), None
patent: WO 2004/087689 (2004-10-01), None
G.M. Coppola, The Chemistry of 4H-3,1 Benzoxazin-4-Ones, J. Heterocyclic Chemistry, 1999, pp. 563-588, vol. 36.
Jakobsen et, al., Inhibitors of the Tissue Factor/Factor VIIA-Induced Coagulation: Synthesis and in Vitro Evaluation of Novel 2-Aryl Substituted Pyrido[3,4-d][1,3], Pyrazino[2,3-d][1,3]-, Pyrimido[4,5-d][1,3]-, Pyrazolo[3,4-d][1,3], Thieno[3,2-d][1,3]- and Thieno[2,3-d][1,3]-Oxazin-4-Ones, Biorganic and Medicinal Chemistry, 2000, pp. 2803-2812, vol. 8.
Jakobsen et. al, Inhibitors of the Tissue Factor/Factor VIIIA-Induced Coagulation: Synthesis and in Vitro Evaluation of Novel Specific 2-Aryl Substituted 4H-3,1-Bezoxazin-4-Ones, Bioorganic and Medicinal Chemistry, 2000, pp. 2095-2103, vol. 8.
D.V. Ramana et. al., Facile Synthesis of 2-Aryl-4H-3,1 Benzoxazin-4-Ones, Org. Prep. Proced. Int., 1993, p. 588, vol. 25.
PCT Search Report for Corresponding International Phase of PCT/US2004/019068.

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