Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-08-24
1998-05-12
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31405
Patent
active
057505578
ABSTRACT:
Benign prostatic hyperplasia (BPH) in male humans is treated by administering to a male patient in which such condition has been diagnosed, an effective BPH treating amount within the range of from 1 ng to 80 mg of melatonin, which may be in the form of a pharmaceutical formulation for use in treating BPH, which comprises, in combination a carrier, diluent or adjuvant, (1) an effective BPH treating amount of melatonin; and optionally (2) antiandrogens, antiestrogens, growth hormones and/or inhibitors of prostatal testosterone reductase; and/or (3) oxazepam or other melatonin receptor profile modifier.
REFERENCES:
Horst et al., Influence of Melatonin in the Human Prostatic Androgen Metabolism in Vitro, Horm. Metabol. Res., vol. 14, p. 54, 1982.
Guess, Epidemiologic Reviews, vol. 14, p. 131 et seq. (1992).
Walsh et al., "J. Clinical Investigation", vol. 72; Nov. 1983, pp. 1772-1777.
Kenji Yamada, "Effects of Melatonin on Reproductive and Accessory organs in Male Rats", Chem. Pharm. Bull. vol. 40 pp. 1066-1068 (1992).
M. Laudon et al, "Methoxytryptamine, a Novel Melatonin Antagonist: Effects on Sexual Maturation . . . ", J. Endocrinol vol. 116 No. 1, 1988, pp. 43-53.
J.A. Moguilevsky et al, "Effects of Melation on the Luteinizing Hormone release Induced . . . ", Proc. Soc. Exp. Biol. Med. vol. 15 No. 4, 1976, pp. 663-666.
Wannee Srivilai et al, "Stereological Changes in Rat Ventral Prostate Induced by Melatonin", J. Pineal Res. vol. 6, No. 2, 1989, pp. 111-119.
Goldberg Jerome D.
Neurim Pharmacueticals Ltd.
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