Method and pharmaceutical composition for reducing serum homocys

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514824, 514 52, 514249, 514345, A61K 3578

Patent

active

061299189

ABSTRACT:
A method and composition are described for reducing the elevated plasma homocysteine level in mammals (humans) by oral administration of a therapeutically effective amount of Allium plants or extracts thereof, preferably garlic, with or without one or more vitamins such as B.sub.6, B.sub.12 and folic acid in an acceptable pharmaceutical carrier. Enhanced effectiveness is achieved with a combination of Allium plants or extracts thereof, preferably garlic, with vitamins such as B.sub.6, B.sub.12 and folic acid. The described method and composition are effective for prevention, treating or ameliorating cardiovascular diseases such as myocardial infarction, stroke and multiple arteriosclerosis by the reduction or prevention of high levels of plasma homocysteine, one of the major causes for such diseases. Methods and compositions are disclosed.

REFERENCES:
patent: 4737364 (1988-04-01), Kalogris
patent: 5231114 (1993-07-01), Awazu
patent: 5612077 (1997-03-01), Hibi
Agarwal, Med. Res. Reviews 16(1):111-124, 1996.
Boushey, C.J., A Quantitative Assessm't of Plasma Homocysteine as a Risk Factor for Vasc. Disease, JAMA, 1995, 274: 1049-1057.
Perry, I.J., Prosp. study of serum tot. homocysteine conc. and risk of stroke in mid-age British men, The Lancet, 1995, 346: 1395-98.
Malinow, M.R., Homocyst(e)ine and arterial occlusive diseases, Journal of Int. Med., 1994; 236: 603-617.
Verhoef, P., Homocysteine Metabolism and risk of M.I.: Rel. with Vit.'s B6, B12, and Folate, Am. J. of Epidemiology, 1996, 143: 845-859.
McCulley, K.S., Homocysteine, Folate, Vitamin B6, and Cardio. Disease, JAMA, 1998, 279: 392-3.
Arnesen, E., Serum Total Homocysteine and Coronary Heart Disease, INt. Journal of Epidemiology, 1995, 24: 704-9.
Rosenberg, I.H., Homocysteine, Vitamins and Arterial Occ. Disease: An Overview, Am. Inst. of Nutrition. J. Nutr., 1996, 126: 1235S-1237S.
Bratterstrom, L., et al., Homocysteine and cysteine: det.'s of plasma levels in mid-aged and elderly sub.'s, J or Int. Med., 1994 236: 633-641.
Graham, I.M., et al., Plasma Homocysteine as Risk Factor for Vasc. Disease, JAMA, 1997, 277: 1775-1781.
Clarke, R., et al., Hyperhomocysteinemia: An Ind. risk factor for Vasc. Disease, The N.E. J. of Med., 1991, 324: 1149-1155.
Selhub, J., et al., Assoc. between Plasma Homocysteine Conc.'s and Extracranial carotid-artery stenosis, The N.E. J. of Med., 1995 332: 286-91.
Stampfer, M.J. et al., A Prospective Study of Plasma Homocyst(e)ine and Risk of M.I. in US Physicians, JAMA, 1992, 268: 877-881.
Cowley, G., The Heart Attackers, Newsweek, Aug. 11, 1997, 55-60.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method and pharmaceutical composition for reducing serum homocys does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and pharmaceutical composition for reducing serum homocys, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and pharmaceutical composition for reducing serum homocys will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2254288

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.