Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1986-02-10
1988-09-13
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 18, 514912, 514954, A61K 3702
Patent
active
047710365
ABSTRACT:
The subject invention concerns a process for the prevention and reversal of cataracts. Specifically, the invention comprises the treatment of the eye lens with an effective cataract inhibiting amount of thioredoxin or thioredoxin-derived, or thioredoxin-like, dithiol peptide, alone, or in combination with a thioredoxin reductase regenerating system. The thioredoxin compound can be administered topically to a patient in need of such treatment on a daily basis over an extended period of time via known delivery techniques such as eye drops and ocular inserts.
REFERENCES:
patent: 4665089 (1987-05-01), Siezen et al.
Spector, A. and Roy, D. (1978) "Disulfide-Linked High Molecular Weight Protein Associated with Human Cataract" Proc. Natl. Aca. Sci. U.S.A., 75:3244-3248.
Garner, M. H. and Spector, A. (1980) "Selective Oxidation of Cysteine and Methionine in Normal and Senile Cataractous Lenses" Proc. Natl. Acad. Sci. U.S.A., 77:1274-1277.
Spector, A. (1984) "The Search for a Solution to Senile Cataracts" Invest. Ophthal. & Vis. Sci., 25:130-146.
Spector, A., Garner, M. H., Garner, W. H., Roy, D., Farnsworth, P. and Shyne, S. (1979) Science, 204:1323-1326, "An Extrinsic Membrane Polypeptide Associated with High-Molecular-Weight Protein Aggregates in Human Cataract."
Spector, A. and Garner, M. H. (1980) "Interaction of Human Cataract Fiber Cell Membrane Polypeptides with Cytoplasmic Components" In Developments in Biochemistry; Red Blood Cells and Lens Metabolism, S. K. Srivastava, Ed., 9:233-236, Elsevier North-Holland, N.Y.
Garner, M. H. and Spector A. (1980) "Sulfur Oxidation in Selected Human Cortical Cataracts and Nuclear Cataracts" Exp. Eye Res., 31:361-369.
Garner, W. H., Garner, M. H. and Spector, A. (1981) "Gamma-Crystallin, a Major Cytoplasmic Polypeptide Disulfide Linked to Membrane Proteins in Human Cataract" Biochem. Biophys. Res. Comm., 98:439-447.
Garner, W. H., Garner, M. H. and Spector, A. (1983) "H.sub.2 O.sub.2 -Induced Uncoupling of Bovine Lens Na.sup.+, K.sup.+ -ATPase" Proc. Natl. Acad. Sci. U.S.A., 80:2044-2048.
Wannemacher, C. F. and Spector, A. (1968) "Protein Synthesis in the Core of Calf Lens" Exp. Eye Res., 7:623-625.
Dilley, K. J. and van Heyningen, R. (1976) "Some Aspects of Human Lens Metabolism: Glycolysis and Protein Synthesis" Doc. Ophthalmol. Proc. Ser., 8:171-175.
Hockwin, O. and Ohrloff, C. (1981) "Enzymes in Normal, Aging and Cataractous Lenses" in Molecular and Cellular Biology of the Eye Lens, H. Bloemendal, Ed. pp. 367-381, John Wiley & Sons, N.Y.
Spector, A., Scotto, R., Weissbach, H. and Brot, N. (1982) "Lens Methionine Sulfoxide Reductase" Biochem. & Biophys. Res. Comm., 108:429-434.
Brot, N., Weissbach, L., Werth, J. and Weissbach, H. (1981) "Enzymatic Reduction of Protein-Bound Methionine Sulfoxide" Proc. Natl. Acad. Sci. U.S.A., 78:2155-2158.
Brot, N., Werth, J., Koster, D. and Weissbach, H. (1982) "Reduction of N--Acetyl Methionine Sulfoxide: A Simple Assay for Peptide Methionine Sulfoxide Reductase" Anal. Biochem., 122:291-294.
Pigiet Vincent P.
Spector Abraham
Brown J. R.
Moezie F. T.
Saliwanchik David R.
Saliwanchik Roman
Trustees of Columbia University in the City of New York
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