Method and means for the early detection and diagnosis of certai

Details Method and means for the early detection and diagnosis of certai Method and means for the early detection and diagnosis of certai

1976-11-29

1979-04-17

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 206569, 424 12, G01N 3316, A61K 4300

Patent

active

041501497

ABSTRACT:
This invention is directed to a method and means for the early detection of a wide variety of cancers, in humans, which method and means consists of the assay and development of a pattern or fingerprint of severally biologically inert, or inactive polypeptides (or perhaps biologically active peptides) in the blood of humans, e.g.: big-ACTH (big-Adrenocorticotropin Hormone), big-.beta.MSH (big-beta melanocyte-stimulating Hormone), the alpha chain of the glycopeptide hormones, the measurement of the arginine vasotocin (AVT), an analogue of Arginine vasopressin, (AVP) (or the combined measurement of AVP and AVT). The values obtained by the assays of each of the foregoing polypeptids is then compared with the individual values and patterns found in humans. If any one of the polypeptide values is elevated above the upper end of the normal values, a carcinoma from some tumor site is suspected; also from the pattern of elevations in one or more peptides, a specific type of cancer may be suspected. The tumor site can then be readily localized. The level of detectability of a carcinoma from a variety of tumor sites, by means of this procedure approaches 100%. Since evidence of these biologically inactive prohormones, fragments and analogues of hormones precedes clinically recognizable ectopic hormone production by months or years, an early, reliably detection system for carcinoma cancers is set forth herein. Assays of each of the polypeptides is performed by means of radioimmunoassay coupled with radioreceptorassay or bioassay, where necessary.

REFERENCES:
ed. Jaffe et al., Methods of Hormone Radioimmunoassay, Academic Press, New York, 1974, pp. 125-159, 161-171, 187-195.
Gewirtz et al., Journal of Clinical Investigation, 53: 1022-1032, 1974.
Tormy et al., Cancer, 35: 1095-1100, 1975.
Baylin, Hospital Practice, Oct. 1975, pp. 117-126.
Braunstein et al., Ann. Int. Med., 78: 39, 1973.
Rees et al., Clinical Endrocrinology, 3: 263-299, 1974.
Odell et al., Ectopic Hormone, Secretion by Tumors in Cancer, ed. Becker, Plenum Press, N.Y., 1975, pp. 81 et seq.
Primack, The Production of Markers by Bronchogenic Carcinoma, A Review Seminars in Oncology, 1: 235, 1974.
Weintraub et al., Metabolism, 22: 1119, 1973.
Croll et al., ed., New Techniques in Tumor Localization and Radioimmunoassay, J. Wiley & Sons, N.Y., 1974, pp. 9-15.

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