Method and means for producing high titer, safe, recombinant len

Details Method and means for producing high titer, safe, recombinant len Method and means for producing high titer, safe, recombinant len

1997-12-12

1999-11-30

Guzo, David

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

4353201, 435325, 435366, 435369, 435465, 435466, C12N 1586, C12N 1564, C12N 510

Patent

active

059941367

ABSTRACT:
Lentiviral vectors modified at the 5' LTR or both the 5' and 3' LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production.

REFERENCES:
Elder et al., Adv. Virus Res. vol. 45, pp. 225-247. 1995.

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