Method and means for producing high titer, safe, recombinant len

Details Method and means for producing high titer, safe, recombinant len Method and means for producing high titer, safe, recombinant len

1999-03-18

2000-12-26

Guzo, David

Chemistry: molecular biology and microbiology

Vector, per se

435455, 435456, C12N 15867

Patent

active

061657824

ABSTRACT:
Lentiviral vectors modified at the 5' LTR or both the 5' and 3' LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production.

REFERENCES:
Elder et al., Adv. Virus Res., vol. 45, pp. 225-247, 1995.

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