Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-04-14
1999-11-02
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, A61K 3805
Patent
active
059770767
ABSTRACT:
The invention provides a method of inhibiting complement in a mammal comprising administering to the mammal an effective amount of a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan--tryptophan. The invention further provides a method of prolonging the survival of tissue transplanted into a mammal comprising administering to the mammal an effective amount of a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan--tryptophan. The invention also provides a method of treating an inflammatory response in a mammal comprising administering to the mammal an effective amount of a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan--tryptophan. Finally, the invention provides a pharmaceutical composition comprising a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan--tryptophan in a pharmaceutically-acceptable vehicle.
REFERENCES:
patent: 3941763 (1976-03-01), Sarantakis
patent: 4546082 (1985-10-01), Kurjan et al.
patent: 4588684 (1986-05-01), Brake
patent: 4775622 (1988-10-01), Hitzement et al.
patent: 4945039 (1990-07-01), Suzuki et al.
patent: 5084398 (1992-01-01), Huston et al.
patent: 5336762 (1994-08-01), Ranney
patent: 5364930 (1994-11-01), Baumann et al.
patent: 5773569 (1998-06-01), Wrighton
Burton et al., 1980, Nature, 288:338-44.
Ellman, 1959 Arch. Biochem. Biophys., 82:70-77.
Kulkarni et al., 1981, Cancer Res., 41:2700-06.
Takada, 1984, Immunophamacology, 8:27-35.
Bach et al., 1995, Nature Medicine, 1(9):869-873.
Bach et al., 1996, Immunology Today, 17(8):379-384.
Baldwin et al., 1995, Transplantation, 59(6):797-808.
Baumann et al., 1990, J. Biol. Chem., 265(30):18414-22.
Blair et al., 1983, J. Immunol. Methods, 59:129-143.
Boackle et al., Nature, 282:742-743 (1979).
Brauer et al., J. Immunol., 151:7240-7248 (1993).
Burton, 1985, Molec. Immunol., 22:161-206.
Burton, 1988, Molec. Immunol., 25:1175-81.
Chou and Fasman, 1978, Adv. Enzym., 47:45-148.
Comis et al., 1985, Biochem. Biophys. Acta, 842(1):45-51.
Cozzi et al., 1995, Nature Medicine, 1(9):964:966.
Davis et al., 1985, Biochem. Int'l., 10:395-404.
DeGrado et al., 1981, J. Am. Chem. Soc., 103:679-81.
Deisenhofer et al., 1978, Hoppe-Seyler's Z. Physiol. Chem. Bd., 359:975-85.
Deisenhofer, 1981, Biochemistry, 20(9):2361-2370.
Duncan and Winter, 1988, Nature, 332:738-40.
Ellman, 1958, Arch. Biochem. Biophys., 74:443-450.
Endo et al., 1983, Ann. Clin. Biochem., 20:163-168.
Erlanger, 1980, Methods in Enzymology, 70:85-104.
Fields, 1972, Meth. Enzymol., 25B:464-68.
Fryer et al., 1995, "Role of Macrophages in Delayed Vascular Xenograft Rejection," pp. 396-397, Surgical Forum, 81st Annual Clinical Congress 1995, vol. XLVI.
Fryer et al., 1995, Transplantation, 59(2):171-176.
Fryer, 1996, "Prolongation of Discordant Xenograft Survival by Inhibition of C1Q Deposition," Abstract for 15th Annual Scientific Meeting for the American Society of Transplant Physicians.
Fryer et al., Inhibition of Porcine Endothelial Cell Lysis by Human Serum Using Peptides Which Inhibit C1q Deposition, Abstract from May 1996 22nd Annual Scientific Meeting, American Society of Transplant Surgeons.
Fryer et al., Inhibition of Porcine Endothelial Cell Lysis by Human Serum Using Peptides Which Inhibit C1q Deposition, Abstract from Aug. 1996 XVI Int'l Congress of the Transplantation Society.
Fryer et al., Inhibition of Porcine Endothelial Cell Lysis by Human Serum Using Peptides Which Inhibit C1q Deposition, Abstract from Oct. 1996 IBC's Second Bi-Annual Symposium on Xeno Transplantation.
Garnier et al., 1978, J. Molec. Biol., 120:97-120.
Gauthier et al., 1982, J. Exp. Med., 156:766-77.
Ghebrehiwet et al., 1993,"The C1q-R Participates in Immunoregulation and Signal Transduction," Behring Inst. Mitt., No. 93, pp. 236-240.
Guedson et al., 1979, J. Histochem. Cytochem., 27(8):1131-39.
Henry (ed), Clinical Diagnosis and Management by Laboratory Method published 16th ed by W.B. Saunders, pp. 1425-1429 (1979).
Hughes-Jones and Gardner, 1978, Immunology, 34:459-63.
Jones et al., 1982, J. Immunol. Meth., 53:201-208.
Jones, 1996, Nature Biotechnology, 14:698-700.
Kennedy, 1994, Transplantation, 57(10):1494-1501.
Lancet et al., 1978, Biochem. Biophys. Res. Commun., 85(2):608-614.
Langone et al., 1982, Adv. Immunol., 32:157-252.
Langone et al., 1978, J. Immunol., 121(1):327-32.
Lukas et al., 1981, J. Immunol., 127(6):2555-60.
Makowka et al., 1995, Transplantation, 59(12):1654-1659.
Marquart et al., 1980, J. Mol. Biol., 141:369-91.
Marques et al., 1993, J. Biol. Chem., 268(14):10393-10402.
Merrifield, 1963, J. Am. Chem. Soc., 85:2149-54.
Moe and Kaiser, 1985, Biochem., 24:1971-76.
One et al., 1969, J. Thor. Cardiovas. Surg., 57:225-229.
Parker et al., 1996, Immunology Today, 17(8):373-378.
Prystowsky et al., 1981, Biochemistry, 20:6349-56.
Reid, 1979, Biochemical J., 179:367-71.
Reid et al., 1982, Biochemical J., 203:559-69.
Romanella et al., 1997, Transplantation, 63(7):1021-1025.
Ryan, 1995, Nature Medicine, 1(9):967-968.
Schaapherder et al., 1994, Transplantation, 57(9):1376-1382.
Schaff et al., 1983, J. Thor. Cardiovas. Surg., 85:434-439.
Seller et al., 1991, Biochem. J., 274:481-490.
Siegel et al., 1983, Clin. Exp. Immunol., 52:157-163.
St.ang.lenheim et al., 1973, Immunochem., 10:501-507.
Takada, 1985, Immunopharmacology, 9:87-95.
Taylor et al., 1982, Mol. Pharmacol., 22:657-66.
Theofilopoulos et al., 1979, Adv. Immunol., 28:89-220.
Theofilopoulos et al., Immunodiagnostics of Cancer, p. 896(M. Decker Inc., New York, NY 1979).
Travis, 1995, Science News, 148:298-301.
Veerhuis et al., 1985, Eur. J. Immunol., 15:881-887.
White, Xeno, 4(3):50-54 (1996).
Zubler et al., 1976, J. of Immunol., 116(1):232-235.
Anderson Byron E.
Fryer Jonathan P.
Lukton David
Ross Sheridan
Tsang Cecilia J.
LandOfFree
Method and material for inhibiting complement does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and material for inhibiting complement, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and material for inhibiting complement will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2135543